conclusions it seems that severe pah aggravates the rv function more severely. results significant tricuspid regurgitation was more prevalent in the pah group than in the ps group (61% vs. 18.5%; p < 0.001). the abnormalities in the rv myocardial performance index, rv areas, and rv fractional area change were significantly more robust in the pah group (all ps < 0.05) despite the higher net rv s...

BACKGROUND Pulmonary arterial hypertension (PAH) in patients with sleep apnoea syndrome (SAS) is classically ascribed to associated chronic obstructive pulmonary disease (COPD). The aim of this retrospective study was to evaluate the possible occurrence of PAH as a complication of SAS in patients without COPD. METHODS Right heart catheterisation was performed in 44 patients with SAS and witho...

P ulmonary arterial hypertension (PAH) is a grave vascular disorder characterised by the obstruction and occlusion of the small pulmonary arteries, primarily through the abnormal proliferation of the endothelial and smooth muscle layers. A clinical diagnosis of pulmonary hypertension (PH) is made when the mean pulmonary arterial pressure (P̄pa) is o25 mmHg at rest. An additional criterion to dif...

BACKGROUND In patients with pulmonary hypertension (PH), duration of vortical blood flow along the main pulmonary artery enables estimation of the mean pulmonary arterial pressure (mPAP) non-invasively. It remains to date not known, if this method is applicable in patients with pulmonary arterial hypertension (PAH) and abnormal aortic-to-pulmonary shunting. CASE PRESENTATION The present case ...

Pulmonary Hypertension (PH), the syndrome of elevated pressure in the pulmonary arteries, is associated with significant morbidity and mortality for affected children. PH is associated with a wide variety of potential underlying causes, including cardiac, pulmonary, hematologic and rheumatologic abnormalities. Regardless of the cause, for many patients the natural history of PH involves progres...

Pulmonary arterial hypertension (PAH) is associated with elevated pulmonary vascular resistance, resulting in increased reflection of pressure and flow waves from distal vessels. The gold standard for assessing PAH is right heart catheterization, an invasive procedure that carries a 5% risk of major complications. We validate a noninvasive method for quantifying pulmonary arterial reflection us...

P ulmonary arterial hypertension (PAH) is a debilitating condition that results in dyspnea and fatigue, impaired exercise capacity, and reduced survival. 1 Modest improvements in 6-minute walk distance (6MWD) can be achieved with endothelial-receptor antagonists, phosphodiesterase type-5 inhibitors, and prostacyclin analogs, 1–3 although the extent of improvement varies according to the cause o...

BACKGROUND Angiotensin-converting enzyme 2 (ACE2), a primary component of the vasoprotective axis in the renin-angiotensin system (RAS), has recently been found to have regulatory actions in hypoxic pulmonary hypertension and monocrotaline-induced pulmonary hypertension. We explored the hypothesis that the level of ACE2 protein contents may be decreased in patients with pulmonary arterial hyper...

Introduction On first glance, a review of pulmonary arterial hypertension (PAH) in a journal that focuses on the health of the elderly may seem out of place. PAH is typically envisioned as a progressively disabling disease in young females. However, PAH is not a disease restricted to the young. Indeed, 20% of the patients followed in our pulmonary hypertension clinic are over the age of 65. Alt...

M O N T R E A L — Obese patients often have a constellation of physiological problems that together can lead to a mistaken diagnosis of pulmonary artery hypertension, according to researchers at Duke University Medical Center in Durham, N.C. The presence of exertional dyspnea in these patients often leads to an echocardiogram and a finding of elevated right ventricular systolic pressure. “Often...