BACKGROUND The purpose of this study was to compare the shaping ability of the ProTaper Universal (PTU; Dentsply Maillefer, Ballaigues, Switzerland), WaveOne (WO; Dentsply Maillefer) and ProTaper Next (PTN; Dentsply Maillefer) in simulated L-shaped and S-shaped root canals respectively. METHODS 30 simulated L-shaped and 30 simulated S-shaped root canals in resin blocks were employed and rando...

The effects of dietary cholesterol and hypothyroidism on the mRNA levels of rat apolipoproteins A-I, A-IV, and E were measured in extracts of rat liver and rat intestine by hybridization to specific cDNA. Four groups, each comprised of six rats, were fed diets consisting of normal laboratory rat chow and either no supplements (control); 5% lard, 1% cholesterol, and 0.3% taurocholic acid (CF); 5...

Thyroid disease is often accompanied by changes in the concentrations of serum lipids and lipoproteins. To evaluate the hepatic contribution to the serum abnormalities in thyroid disease, we examined fatty acid metabolism in perfused livers from pair-fed rats made hypothyroid with propylthiouracil (PTU) or made hyperthyroid by treatment with triiodothyronine (T(3)). The animals treated with T(3...

A T4 suppression test involving 24-h thyroidal 131I uptake was carried out on patients with Graves' disease during therapy with an antithyroid drug. Thirty-three patients received propylthiouracil (PTU) for at least 1 year. Each patient was given 75 micrograms L-T3 daily for 8 days in conjunction with PTU (50 mg/day) at the time of the experiment and then the 24-h thyroidal 131I uptake (post T3...

conclusions our study demonstrates that preconditioning of kidney with chronic ptu administration protects renal tissue against iri and this phenomenon was mediated through no system. the results suggest a potential indication for using ptu to protect the kidney before transplantations and to reduce the risk of tissue rejection afterwards. background renal ischemia/reperfusion injury (iri) is a...

In eight patients receiving 0.1 mg T4 daily, administration of PTU resulted in a prompt fall in mean serum T3 concentrations from 78±6 ng/100 ml (SEM) to 61±3 ng/100 ml after 1 day. The mean serum Ts concentrations ranged from 55 to 60 ng/100 ml during the remainder of the PTU treatment period (P < 0.01): The mean control serum TSH concentration was 29.6 AU/ml and it increased to a peak of 40 /...

Propylthiouracil (PTU) is often used to produce experimental hypothyroidism. In general, PTU generates hepatotoxicity, albeit with dissimilar incidence rates of hepatotoxicity. This study examined the hepatoprotective effects Saussurea lappa root ethanol extract on experimentally induced hepatotoxicity in female rats. For this study, 25 adult albino rats were placed into five equal groups: cont...

We present a case of neonatal goiter caused by exposure to propylthiouracil (PTU) during pregnancy in this report. The mother was treated with PTU while pregnant and had history Graves' illness. baby neck tumor having breathing problems when they were first seen. A big thyroid gland detected CT scan. This instance serves as reminder the significance managing maternal appropriately well requirem...

Effect of propylthiouracil (PTU)-induced hypothyroidism during the prepubertal period, at a dose of oneg per kg of the diet, on serum testosterone level and seminal characteristics of Fars indigenous chickens wasstudied. PTU was fed between 7th to 13th weeks of age and semen was collected at weekly intervals, starting at 21st week of age and continued for seven weeks. The effect of PTU treatmen...

UNLABELLED A 57-year-old female presented 17 days after treatment with radioactive iodine (RAI) for difficult-to-control hyperthyroidism. She was febrile, had a sinus tachycardia, and was clinically thyrotoxic. Her thyroid function tests showed a suppressed TSH <0.02 mU/l, with free thyroxine (FT4) >75 pmol/l and total triiodothyronine (TT3) 6.0 nmol/l. She was diagnosed with thyroid storm and ...