نتایج جستجو برای: pts1 signal

تعداد نتایج: 418490  

Journal: :Journal of cell science 1995
M L Slawecki G Dodt S Steinberg A B Moser H W Moser S J Gould

Zellweger syndrome, neonatal adrenoleukodystrophy, infantile Refsum's disease, and classical rhizomelic chondrodysplasia punctata are lethal genetic disorders caused by defects in peroxisome biogenesis. We report here a characterization of the peroxisomal matrix protein import capabilities of fibroblasts from 62 of these peroxisome biogenesis disorder patients representing all ten known complem...

Journal: :Molecular and cellular biology 1999
G K Will M Soukupova X Hong K S Erdmann J A Kiel G Dodt W H Kunau R Erdmann

Pex14p is a central component of the peroxisomal protein import machinery, which has been suggested to provide the point of convergence for PTS1- and PTS2-dependent protein import in yeast cells. Here we describe the identification of a human peroxisome-associated protein (HsPex14p) which shows significant similarity to the yeast Pex14p. HsPex14p is a carbonate-resistant peroxisomal membrane pr...

Journal: :The Journal of biological chemistry 1998
G Lametschwandtner C Brocard M Fransen P Van Veldhoven J Berger A Hartig

Pex5p is the receptor for the peroxisomal targeting signal 1 (PTS1) that consists of a C-terminal tripeptide (consensus (S/A/C)(K/R/H)(L/M)). Hexadecapeptides recognized by Pex5p from Homo sapiens and Saccharomyces cerevisiae were identified by screening a two-hybrid peptide library, and the targeting ability of the peptides was demonstrated using the green fluorescent protein as reporter. The ...

Journal: :Plant physiology 2003
Aaron H Liepman Laura J Olsen

Plant peroxisomal glyoxylate aminotransferases play central roles within the photorespiratory pathway. Genes encoding glyoxylate aminotransferases have been isolated from several animals and microbes, but only recently have plant homologs been identified. Three Arabidopsis homologs of alanine (Ala):glyoxylate aminotransferase 2 (AGT2) contain a putative type 1 peroxisomal targeting signal (PTS1...

2014
Sarah E. Burkhart Yun-Ting Kao

Peroxisomal matrix proteins carry peroxisomal targeting signals (PTSs), PTS1 or PTS2, and are imported into the organelle with the assistance of peroxin (PEX) proteins. From a microscopy-based screen to identify Arabidopsis (Arabidopsis thaliana) mutants defective in matrix protein degradation, we isolated unique mutations in PEX2 and PEX10, which encode ubiquitin-protein ligases anchored in th...

2013
Yumi Mizuno Yuichi Ninomiya Yutaka Nakachi Mioko Iseki Hiroyasu Iwasa Masumi Akita Tohru Tsukui Nobuyuki Shimozawa Chizuru Ito Kiyotaka Toshimori Megumi Nishimukai Hiroshi Hara Ryouta Maeba Tomoki Okazaki Ali Nasser Ali Alodaib Mohammed Al Amoudi Minnie Jacob Fowzan S. Alkuraya Yasushi Horai Mitsuhiro Watanabe Hiromi Motegi Shigeharu Wakana Tetsuo Noda Igor V. Kurochkin Yosuke Mizuno Christian Schönbach Yasushi Okazaki

Peroxisomes are subcellular organelles involved in lipid metabolic processes, including those of very-long-chain fatty acids and branched-chain fatty acids, among others. Peroxisome matrix proteins are synthesized in the cytoplasm. Targeting signals (PTS or peroxisomal targeting signal) at the C-terminus (PTS1) or N-terminus (PTS2) of peroxisomal matrix proteins mediate their import into the or...

Journal: :Molecular biology of the cell 2005
Andrew W Woodward Bonnie Bartel

Plant peroxisomal proteins catalyze key metabolic reactions. Several peroxisome biogenesis PEROXIN (PEX) genes encode proteins acting in the import of targeted proteins necessary for these processes into the peroxisomal matrix. Most peroxisomal matrix proteins bear characterized Peroxisomal Targeting Signals (PTS1 or PTS2), which are bound by the receptors PEX5 or PEX7, respectively, for import...

Journal: :Molecular biology of the cell 2006
Lan Zhang Sébastien Léon Suresh Subramani

Among peroxins involved in peroxisome biogenesis, only Pex8p is predominantly intraperoxisomal at steady state. Pex8p is necessary for peroxisomal matrix protein import via the PTS1 and PTS2 pathways. It is proposed to bridge two peroxisomal membrane subcomplexes comprised of the docking (Pex13p, Pex14p, Pex17p) and RING (Pex2p, Pex10p, Pex12p) peroxins and is also implicated in cargo release o...

Journal: :The Journal of Cell Biology 1995
A Motley M J Lumb P B Oatey P R Jennings P A De Zoysa R J Wanders H F Tabak C J Danpure

Alanine/glyoxylate aminotransferase 1 (AGT) is peroxisomal in most normal humans, but in some patients with the hereditary disease primary hyperoxaluria type 1 (PH1), AGT is mislocalized to the mitochondria. In an attempt to identify the sequences in AGT that mediate its targeting to peroxisomes, and to determine the mechanism by which AGT is mistargeted in PH1, we have studied the intracellula...

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