نتایج جستجو برای: ptk

تعداد نتایج: 1449  

2011
Xiu E. Feng Wan Yi Zhao Shu Rong Ban Cheng Xiao Zhao Qing Shan Li Wen Han Lin

A series of new benzophenone and diphenylmethane halophenol derivatives were prepared. Their structures were established based on (1)H NMR, (13)C NMR and HRMS data. All prepared compounds were screened for their in vitro protein tyrosine kinase (PTK) inhibitory activities. The effects of modification of the linker, functional groups and substituted positions at the phenyl ring on PTK inhibitory...

Journal: :The Journal of pharmacology and experimental therapeutics 2001
S Doolen N R Zahniser

The dopamine (DA) transporter (DAT) regulates dopaminergic synaptic transmission by controlling extracellular levels of DA. Thus, understanding signaling mechanisms that alter DAT function is critical for understanding dopaminergic neurotransmission. We have expressed the human DAT (hDAT) in Xenopus laevis oocytes to test the hypothesis that protein tyrosine kinases (PTKs) acutely regulate DAT ...

Journal: :Brain research 2000
Q Jiang Z Gu G Zhang G Jing

Extracellular signal-regulated kinases (ERK1/ERK2) have been shown transiently activated and involved in excitotoxicity. We searched for upstream molecules responsible for the regulation of glutamate-induced ERK1/ERK2 activation and ERK1/ERK2-mediated apototic-like death in cultured rat cortical neurons. ERK1/ERK2 activation (monitored by anti-active ERK1/ERK2 antibody) was almost completely pr...

Journal: :Arquivos brasileiros de oftalmologia 2012
Belquiz Rodrigues do Amaral Nassaralla João Jorge Nassaralla Junior

PURPOSE To determine the ten-year visual results and outcomes of excimer laser phototherapeutic keratectomy (PTK) for recurrent corneal erosions. METHODS Twenty-six eyes of 23 patients with recurrent corneal erosions were treated by PTK from 1996 to 2000 at the Goiania Eye Institute, Brazil. All eyes had failed to respond to conventional therapy. Data regarding preoperative and postoperative ...

Journal: :American journal of physiology. Renal physiology 2002
Yuan Wei Wen-Hui Wang

We have previously demonstrated that inhibiting protein tyrosine kinase (PTK) and stimulating protein kinase A (PKA) increase the activity of the small-conductance K (SK) channel in the cortical collecting duct (CCD) of rat kidneys (Cassola AC, Giebisch G, and Wang WH. Am J Physiol Renal Fluid Electrolyte Physiol 264: F502-F509, 1993; Wang WH, Lerea KM, Chan M, and Giebisch G. Am J Physiol Rena...

Journal: :The Journal of Cell Biology 1992
K L McDonald E T O'Toole D N Mastronarde J R McIntosh

We have analyzed the fine structure of 10 chromosomal fibers from mitotic spindles of PtK1 cells in metaphase and anaphase, using electron microscopy of serial thin sections and computer image processing to follow the trajectories of the component microtubules (MTs) in three dimensions. Most of the kinetochore MTs ran from their kinetochore to the vicinity of the pole, retaining a clustered arr...

Journal: :Japanese journal of ophthalmology 1998
T Ishikawa A Hirano J Inoue K Nakayasu A Kanai K Takeuchi T Kanda

We reviewed the SRK-II method and introduce a new equation to calculate the intraocular lens (IOL) power for eyes which underwent laser phototherapeutic keratectomy (PTK). The Gullstrand series was used to determine the power and the radius of curvature of planoconvex IOLs which alter the focal point from the cornea to reach the conjugate point on the retina. The radius of anterior corneal curv...

Journal: :The Biochemical journal 1998
K Cheng J G Koland

The nucleotide-binding properties of wild-type epidermal- growth-factor (EGF)-receptor protein tyrosine kinase (PTK) and EGF-receptor mutants with site-specific amino acid substitutions known to attenuate protein kinase activity were analysed by a fluorescence competition assay employing the nucleotide analogue 2'(3')-O-(2,4,6-trinitrophenyl)adenosine 5'-triphosphate. Binding affinities for ATP...

Journal: :Journal of Korean Medical Science 1993
I. S. Kim S. B. Lee K. C. Cho

We attempted to study the role of protein tyrosine kinase (PTK) and protein kinase C (PKC) in the cascade of phosphorylation of ribosomal protein S6 during differentiation of leukemic cells (HL-60, THP-1, and RWLeu-4). Neither activation nor inhibition of colony stimulating factor-1 (CSF-1) receptor's PTK activity with CSF-1 or genistein respectively affected the phosphorylation of S6. However,...

Journal: :The Journal of pharmacology and experimental therapeutics 2005
Latchezar D Todorov Svetlana T Mihaylova-Todorova Sophie M Choe David P Westfall

Experiments were carried out to examine the effects of protein tyrosine kinase (PTK) and protein tyrosine phosphatase inhibitors on the purinergic contraction of the guinea pig vas deferens. Sodium orthovanadate (SOV) produced a robust increase of the amplitude of contractions evoked by both neurogenic electrical field stimulation and exogenous ATP. This effect of SOV was concentration- and tim...

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