Background: High-velocity carbon ion beams represent the most advanced tool for radiotherapy of deep-seated tumors. Currently, the superiority of carbon ion therapy is more prominent on lung cancer or hepatomas. Materials and Methods: The data for lateral straggling and projected range of monoenergetic 290 MeV/u (3.48 GeV) carbon ions in muscle tissue were obtained from the stopping and range o...

We summarize recent results and ongoing activities in mathematical algorithms computer science methods related to proton computed tomography (pCT) intensity-modulated particle therapy (IMPT) treatment planning. Proton necessitates a high level of delivery accuracy exploit the selective targeting imparted by Bragg peak. For this purpose, pCT utilizes beam itself create images. The technique work...

Hadron therapy with protons has advantages respect to conventional radiotherapy because of the maximization dose at Bragg peak. As a drawback, and different systematic uncertainty sources, quasi-real time monitoring for proton range verification is required reduce safety margins. In this respect, two gamma-ray imaging techniques are pursued: prompt positron-annihilation tomography (PET). The pr...

Many new techniques for delivering radiation therapy are being developed for the treatment of cancer. One of these, proton therapy, is becoming increasingly popular because of the precise way in which protons deliver dose to the tumor volume. In order to achieve this level of precision, extensive treatment planning needs to be carried out to determine the optimum beam energies, energy spread (w...

There are few reports on the biological homogeneity within the spread-out Bragg peak (SOBP) of proton beams. Therefore, to evaluate the relative biological effectiveness (RBE) and the oxygen enhancement ratio (OER), human salivary gland tumor (HSG) cells were irradiated at the plateau position (position A) and three different positions within a 6-cm-wide SOBP (position B, 26 mm proximal to the ...

We investigated the relative biological effectiveness (RBE) of therapeutic proton beams at six proton facilities in Japan with respect to cell lethality of HSG cells. The RBE of treatments could be determined from experimental data. For this purpose, we used a cell survival assay to compare the cell-killing efficiency of proton beams. Among the five linear accelerator (LINAC) X-ray machines at ...

BACKGROUND Proton radiotherapy is a form of charged particle therapy that is preferentially applied for the treatment of tumors positioned near to critical structures due to their physical characteristics, showing an inverted depth-dose profile. The sparing of normal tissue has additional advantages in the treatment of pediatric patients, in whom the risk of secondary cancers and late morbidity...