Impact of gestational diabetes mellitus (GDM) on the coagulation system still remains unclear and there is limited data available regarding haemostatic changes in GDM Bangladesh. This study was aimed at determining plasmaprothrombin time (PT), activated partial thromboplastin (APTT) women with GDM. cross sectional encompassed 44 (age: 28.5±3.8 years, BMI: 27.2±4.0kg/m2; mean±SD) equal number pr...

Objective: To assess the coagulation test abnormalities (prothrombin time, activated partial thromboplastin time and fibrin degradation products) in dengue fever patients its impact on clinical outcomes of patient.
 Study Design: Cross-sectional study.
 Place Duration Study: Hematology Department, Pakistan Naval Ship Shifa Hospital, Karachi Pakistan, from Aug 2016 to Feb 2017.
 M...

By SAMUEL I. RAPAPORT, S r A BETH AMES AND BARBARA J. DUVALL C ONLEY AND HARTMANN’ first called attention to a plasma coagulation disturbance peculiar to patients with systemic lupus erythematosus or closely related dysproteinemias. Its characteristics are a long whole blood and/or recalcified plasma clotting time, a long Quick “prothrombin” time, and the presence of a circulating anticoagulant...

Interaction of certain metal ions with prothrombin and prothrombin fragment 1 has been shown to result in conformational change(s). Self-association of prothrombin and prothrombin fragment 1 in the presence of divalent cations has been reported. The present study has made use of a covalent cross-linking reagent, dithiobis(succinimidylpropionate), to study the self-association of prothrombin in ...

The amino acid sequence of the nonthrombin half of human prothrombin is presented. Prothrombin fragment 1 has 155 amino acid residues as compared with 156 for the bovine equivalent. Ten gamma-carboxyglutamic acid residues are at the same location in each species. Human prothrombin fragment 2 contains 118 amino acid residues, as does the similar bovine fragment. Comparing bovine and human prothr...