background: intrauterine growth retardation (iugr) contributes significantly to fetal morbidity and mortality, but its etiology is unknown in most cases. objective: the aim of this study was to examine the association between inherited thrombophilia and iugr. materials and methods: a case-control study was performed in a tertiary referral center (afzalipour hospital) over 2-years period (2010-2...

Laparoscopic cholecystectomy is now the gold standard for the treatment of symptomatic cholelithiasis. Portal venous thrombosis after laparoscopic cholecystectomy is rare. We report a case of thrombosis of the portal venous system after laparoscopic cholecystectomy in a patient with a latent prothrombin gene mutation. An abdominal computed tomography and magnetic resonance angiogram of the abd...

Abstract Objective To study the association between high activity of Factor II (prothrombin) in blood plasma with G20210A mutation and development great obstetrical syndromes. Material methods A prospective clinical cohort was conducted on 290 pregnant women (average age 31.7 ± 4.7 years old). The main group made up 140 patients, while control comprised 150 wild G20210G type. aim to evaluate ve...

Aim: This study aimed to investigate the relationship between severe novel coronavirus pneumonia (NCP) and hypercoagulable conditions that predispose patients thrombosis such as prothrombin gene ( F2) rs1799963 (G20210A), factor V Leiden F5) rs6025 (G1691A) PAI-1 (rs1799768). Patients: NCP-diagnosed 62 previously healthy were enrolled for investigation of thrombophilia-related polymorphisms. Ma...

1. Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, De Ronde H, Van der Velden PA, Reitsma PH: Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 369:64, 1994 2. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM: A common genetic variation in the 38-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin le...