Methamphetamine (Meth) is recognized as one of the most important new distributedabused drug that causes severe damage to the different parts of the brain, especiallyhippocampus. Previous studies have demonstrated that Meth can induce apoptosis and celldeath in the brain. In this study, we evaluated the long-term effects of Meth abuse in theCA1 region of postmortem hippo...

Abstract Background and Aims Ischemia/reperfusion injury (IRI), a participant in acute kidney (AKI), can occur as series of pathological processes such inflammation. Linarin (LIN) has been widely used for different diseases. To confirm the anti-inflammatory value relevant mechanism LIN during IRI, vivo vitro model were established. Method or isovolumetric DMSO was given, histologic analysis, qu...

Abstract Purpose The extracellular electron transfer (EET) capability enables electroactive microorganisms have a wide range of applications in energy production, wastewater treatment, bioremediation and chemical synthesis. Because the oxygen levels will sharply affect EET process, we integrated transcriptome changes under different with protein–protein interaction (PPI) network to study specif...

The increasing amount of available Protein-Protein Interaction (PPI) data enables scalable methods for the protein complex prediction. A protein complex is a group of two or more proteins formed by interactions that are stable over time, and it generally corresponds to a dense sub-graph in PPI Network (PPIN). However, dense sub-graphs correspond not only to stable protein complexes but also to ...

Discovering the interactions between proteins mentioned in biomedical literatures is one of the core topics of text mining in the field of life science.In this paper, we propose a system under interaction pattern generation approach to capture frequent PPI patterns in text with the use of official BioC API and Semantic Class Labeling. We also present an interaction pattern tree kernelme...

aim: this study is aimed to elicit the possible correlation between breast and colon cancer from molecular prospectiveby analyzing and comparing pathway-based biomarkers.background: breast and colon cancer are known to be frequent causes of morbidity and mortality in men and womenaround the world. there is some evidence that while the incident of breast cancer in young women is high, it is repo...

Hepatocellular carcinoma (HCC) is a worldwide malignant tumor that caused irreversible consequences. Tanshinone IIA has been shown to play notable role in HCC treatment. However, the potential targets and associating mechanism of against remain unknown. We first screened out 105 overlapping genes by integrating predicted from multiple databases differentially expressed Cancer Genome Atlas (TCGA...

This study aimed to explore the possible target and mechanism of wheel treadmill (WTM) test for motor function recovery spinal cord injury (SCI). Rats were divided into sham, control WTM groups establish an SCI mode. in group trained on test, Basso–Beattie–Bresnahan (BBB) scores determined. The samples collected, mRNA sequencing was conducted determine changes gene expression. coexpressed genes...