Malnutrition in cirrhotic patients is extremely common and has a multifactorial aetiology, whose constitutive elements have not been completely elucidated yet. Protein depletion particularly important an imbalance of hormones regulating hunger satiety may be additive factor. The diagnosis treatment malnutrition are since associated with higher complication rates mortality. Our observational stu...

We examined the mechanisms responsible for the decrease in HDL cholesterol (HDL-C) levels after the consumption of a diet low in total fat, saturated fat, and cholesterol. Twenty-one subjects with a mean age of 58+/-12 years were placed on a baseline isocaloric diet (15% protein, 49% carbohydrate, 36% fat, and 150 mg/1000 kcals of cholesterol) and then switched to an NCEP Step 2 diet (15% prote...

In cell cultures of Walker rat carcinoma ~56, DL-leucine-l-C 14 was incorporated into cell proteins and converted to C~402 at similar rates. The protein catabolic rates of the cell cultures were studied by labeling the cell proteins with leucine-l-C 14 and measuring the subsequent transfer of radioactivity into the culture medium. The cell protein catabolic rate--i .e. , the percentage of the i...

Malnutrition inflammation complex syndrome (MICS) occurs in maintenance haemodialysis (MHD) patients and is a strong predictor of morbidity and mortality in these patients. The aim of our study was to evaluate the influence of inflammation on the biochemical and anthropometrical parameters of the nutritional status in MHD patients. Our study was made on 154 patients (93 men and 61 women, mean a...

In cell cultures of Walker rat carcinoma ~56, DL-leucine-l-C 14 was incorporated into cell proteins and converted to C~402 at similar rates. The protein catabolic rates of the cell cultures were studied by labeling the cell proteins with leucine-l-C 14 and measuring the subsequent transfer of radioactivity into the culture medium. The cell protein catabolic rate--i .e. , the percentage of the i...

The turnover of prothrombin and of factor X was investigated in rabbits fed on a 1%-cholesterol-supplemented or a standard diet by studying the evolution of radioactivity in blood and in plasma from these animals after the intravenous injection of either 125I-rabbit factor X or 125I-bovine prothrombin. For factor X, half-lives and fractional pool sizes were similar for the two groups of rabbits...

Although hyperinsulinemia and decreased high density lipoprotein cholesterol concentration can occur in patients with hypertension, there is no information available concerning the dynamic state of high density lipoprotein metabolism. To address this issue, we quantified high density lipoprotein turnover in 12 patients with mild hypertension and 11 matched subjects with normal blood pressure. P...

Despite the strong association between protein catabolic conditions and hyperglucagonemia, and enhanced glucagon secretion by amino acids (AA), glucagon's effects on protein metabolism remain less clear than on glucose metabolism. To clearly define glucagon's catabolic effect on protein metabolism during AA load, we studied the effects of glucagon on circulating AA and protein dynamics in six h...