Objective(s): The stress-responsive genes of Sestrin family are recognized as new tumor suppressor genes in breast carcinoma, however, the function of Sestrin family in human prostate cancer is not clear. Ionizing radiation (IR) is known to induce Sestrin gene expression in breast cancer cells. However, the response of Sestrin to IR has not been reported in PC3 prostate cancer cells. Materials ...

background : a single nucleotide variation within  atechol-o-methyl transferase (comt) gene may alter the comt enzyme activity level. polymorphism of val158met in the comt gene has been related to malignancy. in this regard, a study was carried out to find a possible association between the comt gene polymorphism in patients with sporadic prostate cancer (pca) and benign prostatic hyperplasia (...

Background: According to the EAU guidelines, a life expectancy of more than 10 years is considered an important factor in the treatment of prostate cancer. The Charlson score is used to predict mortality based on comorbidies.The purpose of this study was to investigate the relationship between age, Charlson score and outcome in patients with cT3a prostate cancer. Materials and Methods: Between ...

objective(s): bonenavi, a computer-aided diagnostic system, is used in bone scintigraphy. this system provides the artificial neural network (ann) and bone scan index (bsi) values. ann is associated with the possibility of bone metastasis, while bsi is related to the amount of bone metastasis. the degree of uptake on bone scintigraphy can be affected by the type of bone metastasis. therefore, t...

we report our experience with 124 patients were referred 70 our urology clinic in sina hospital for urinary retention. serum psa analyzed by using a monoclonal assay. all patients underwent digital rectal examination. the patients devided in 3 groups: group 1 (87 men) with a serum psa level less than 4 ng/ml, group 2 (26 men) with a serum psa level 4-10 ng/ml and group 3 (11 men) with a serum p...

68Ga Prostate-specific membrane antigen (PSMA) is an increasingly popular radiopharmaceutical tracer in prostate cancer and is becoming increasingly researched in other cancers such as breast cancer, renal cell carcinoma, glioblastoma multiforme, among others. Cholangiocarcinoma is the second most common primary hepatic malignant tumor; it is an aggressive tumor with a 5-year surviva...

background: prostate cancer has been reported as the second leading cause of cancer death among men in 2013. prevention and early detection of cancer are considered as critical factors in controlling the disease and increasing the survival of patients. therefore, we aimed to investigate the effect of health belief model (hbm)-based education on knowledge and prostate cancer screening behaviors ...

this study aimed to determine the prevalence of anxiety among prostate cancer patients, and to ascertain the association between stress status, socio-demographic, medical and surgical illness, current urinary problem and cancer status with general health-related quality of life (hrqol) among these patients.a hospital based, cross sectional study was conducted at surgical clinic, university mala...