نتایج جستجو برای: propoxy methylphenyl oxasiazole derivatives

تعداد نتایج: 106493  

Journal: :Chemical & pharmaceutical bulletin 2002
Toshiya Noguchi Akira Onodera Kazuyuki Tomisawa Sadakazu Yokomori

An efficient and practical procedure for the synthesis of esonarimod, (R,S)-2-acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid (1), a new antirheumatic drug, has been developed. The intermediate, 2-methylene-4-(4-methylphenyl)-4-oxobutanoic acid (2), was prepared by Friedel-Crafts acylation of toluene with itaconic anhydride (3) in the presence of aluminum trichloride and nitrobenzene in ...

Journal: :Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2011
Yuting Chen Liang Wan Daopeng Zhang Yongzhong Bian Jianzhuang Jiang

A series of six Bodipy derivatives, namely 4,4-difluoro-8-(4-amidophenyl)-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene (1), 4,4-difluoro-8-(4-methylphenyl)-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene (2), 4,4-difluoro-8-(4-nitrylphenyl)-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene (3), 4,4-difluoro-8-(4-amidophenyl)-3,5-dimethyl-4-bora-3a,4a-diaza-s-indacene (4), 4,4-difluoro-8-...

Journal: :iranian journal of basic medical sciences 0
maryam iman chemical injuries research center, baqiyatallah university of medical sciences, tehran, iran atefeh saadabadi department of medicinal chemistry, pharmaceutical sciences branch, islamic azad university, tehran, iran asghar davood department of medicinal chemistry, pharmaceutical sciences branch, islamic azad university, tehran, iran

objective(s): recently, phthalimide derivatives were designed based on ameltolide and thalidomide as they possess a similar degree of anticonvulsant potency due to their phenytoin-like profile. the ability of phthalimide pharmacophore to interact with neuronal voltage-dependent sodium channels was studied in the batrachotoxin affinity assay. therefore, in the present study, a series of 19 compo...

Asghar Davood, Atefeh Saadabadi Maryam Iman,

  Objective(s): Recently, phthalimide derivatives were designed based on ameltolide and thalidomide as they possess a similar degree of anticonvulsant potency due to their phenytoin-like profile. The ability of phthalimide pharmacophore to interact with neuronal voltage-dependent sodium channels was studied in the batrachotoxin affinity assay. Therefore, in the present study, a series of 19 com...

Journal: :Acta Crystallographica Section E Structure Reports Online 2010

Journal: :Antimicrobial agents and chemotherapy 2005
C Ying A Holy D Hocková Z Havlas E De Clercq J Neyts

Novel acyclic nucleoside phosphonates with a pyrimidine base preferentially containing an amino group at C-2 and C-4 and a 2-(phosphonomethoxy)ethoxy or (R)-2-(phosphonomethoxy)propoxy group at C-6 selectively inhibit the replication of wild-type and lamivudine-resistant hepatitis B viruses. The activity of the most potent compounds was comparable to that of adefovir.

2010
Payam Khazaeli Mamoud Reza Heidari Alireza Foroumadi Mehdi Kalati

Evaluation the antinociceptive and antiinflammatory effect, of new rigid, propoxy benzopyrane-3,4 Di-hydroxychalcone derivative by Hot-plate, Formaline and Plethysmography Payam Khazaeli, Mamoud Reza Heidari, Alireza Foroumadi, Mehdi Kalati From 1 International Congress on Neurobiology and Clinical Psychopharmacology and European Psychiatric Association Conference on Treatment Guidance Thessalo...

Journal: :Journal of environmental quality 2003
Mark B David Lowell E Gentry Karen M Starks Richard A Cooke

The occurrence of metabolites of many commonly used herbicides in streams has not been studied extensively in tile-drained watersheds. We collected water samples throughout the Upper Embarras River watershed [92% corn, Zea mays L., and soybean, Glycine max (L.) Merr.] in east-central Illinois from March 1999 through September 2000 to study the occurrence of atrazine (2-chloro-4-ethylamino-6-iso...

2014
Batool Rahmati Mohammad Mirzaei Mohsen Khalili Abbas Ahmadi

Background and Objective: Regarding the prevalence of epilepsy in human society and with respect to insufficiency of usual treatments, new strategies and methods for medical treatment of epileptic patients are necessary. As NMDA receptor antagonists are the most prominent anti-epileptic drugs, in the present study, we synthesized and investigated anti-epileptic effect of a new piperidine deriva...

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