BACKGROUND Caesarean delivery (CD) increases the risk of postpartum infection by 5 to 20 fold. Prevention of surgical site infection (SSI) is the goal of antibiotic prophylaxis. This study was carried out to assess the optimum timing for prophylactic antibiotic administration and to assess the amount of the antibiotic crossing the placental barrier. METHODS Eligible mothers were recruited, af...

BACKGROUND The effectiveness of prophylactic antibiotics has not been established for patients who undergo plastic surgery as outpatients, and consensus guidelines for antibiotic administration in clean-contaminated plastic surgery are not available. OBJECTIVES In a retrospective study of outpatients, the authors examined preoperative timing of prophylactic antibiotics, whether postoperative ...

OBJECTIVE This study documents the current practice of perioperative prophylactic methods used for cataract surgery in Yemen. It investigates the routine practice in antibiotic and antiseptic use in preventing postoperative endophthalmitis. METHODS This is a non-comparative survey. A telephone interview survey was conducted with 100 ophthalmologists' from different governorates in Yemen in Se...

BACKGROUND AND AIM The use of prophylactic antibiotics to prevent infection and reduce mortality in patients with acute necrotizing pancreatitis (ANP) remains controversial. The aim of this study is to perform a systematic review of the data from randomized controlled trials to compare prophylactic antibiotic treatment of patients with ANP versus placebo. METHODS A computerized literature sea...

PURPOSE To determine whether prophylactic antibiotic use in patients with orbital fracture prevent orbital infection. DESIGN Retrospective cohort study. PARTICIPANTS All patients diagnosed with orbital fracture between January 1, 2008 and March 1, 2014 at The George Washington University Hospital and Clinics. MAIN OUTCOME MEASURES Development of orbital infection. RESULTS One hundred se...

OBJECTIVE To determine the rate of prophylactic antibiotics usage in uncomplicated gynecologic abdominal surgery in Siriraj Hospital, before and after guideline implementation. MATERIAL AND METHOD Two hundred and fifty-eight women who underwent elective gynecologic surgery for a benign condition were enrolled. The patients were divided into two groups, before and after guideline implementatio...

A cohort study was carried out at the Marilia Medical School Hospital. In the first phase the pattern of antibiotic use was evaluated. Antibiotics were prescribed for 55.4% of the patients; antibiotic combinations were used in 43%. Therapeutic use of antibiotics was considered inadequate in 27%. Respiratory and skin infections were the most frequently diagnosed. In up to 31% of the cases the tr...

Two converging factors highlight the need to optimize the use of prophylactic antibiotics in surgery. First, there is an increasing global emergence of antimicrobial resistance. The problem is complex and multi-faceted, but the selective force of overuse of antibiotics plays an important role. The second factor is the transition to the era of managed care requiring both cost containment and qua...