Carboxylated, sulfated and/or phosphorylated surfaces are admitted as potential optimal templates for biomimetic deposition of calcium phosphate (CaP) coatings in view of improving implants' osseointegration. Layer-by-layer films were built up consisting of anionic chondroitin sulfate (ChS), a biological carboxylated and sulfated polysaccharide and cationic poly(l-lysine) (PLL). The films were ...

Cell sheet engineering has emerged as a novel approach to effectively deliver seeding cells for tissue regeneration, and developing human bone marrow mesenchymal stem cell (hBMMSC) sheets with high osteogenic ability is a constant requirement from clinics for faster and higher-quality bone formation. In this work, we fabricated biocompatible and safe chitosan (CS)/hyaluronic acid (HA) nanoparti...

Therapeutic monoclonal antibodies have become molecules of choice to treat autoimmune disorders, inflammatory diseases, and cancer. Moreover, bispecific/multispecific antibodies that target more than one antigen or epitope on a target cell or recruit effector cells (T cell, natural killer cell, or macrophage cell) toward target cells have shown great potential to maximize the benefits of antibo...

BACKGROUND Fibronectin (FN) is associated with tumorigenesis and progression in bladder cancer, however, the underlying mechanisms causing this remain largely unknown. Furthermore, cancerous inhibitor of protein phosphatase 2A (CIP2A) has been shown to play important regulatory roles in cancer proliferation. Here, we investigated whether FN regulates CIP2A expression to promote bladder cancer c...

InGaAs/InP devices suitable as Single-Photon Avalanche Diodes (SPADs) for photon counting and photon timing applications in the near-infrared provide good detection efficiency and low time jitter, together with fairly low darkcount rate at moderately low temperatures. However, their performance is still severely limited by the afterpulsing effect, caused by carriers trapped into deep levels dur...

Introduction: Amphotericin B (AB) is the drug of choice for treatment several systemic fungal infections. Despite its effectiveness and minimum relation to resistance, AB toxic animal cells, in particular kidney cells. Objective: To address aspects nephrotoxicity biomarkers available early detection disease caused by AB. Method: The bibliographic search was performed online databases. Papers pu...

With the proliferation of wireless applications, electromagnetic (EM) space is becoming more and crowded complex. This makes it a challenging task to accommodate growing number radio systems with limited resources. In this article, by considering EM as ecosystem, leveraging analogy natural ecosystem in biology, novel symbiotic communication (SC) paradigm proposed through which relevant systems,...

In engineering applications, many real-world optimization problems are nonlinear with multiple local optimums. Traditional algorithms that require gradients not suitable for these problems. Meta-heuristic popularly employed to deal because they can promisingly jump out of optima and do need any gradient information. The arithmetic algorithm (AOA), a recently developed meta-heuristic algorithm, ...

Flow states represent a form of optimal experience and contribute to higher levels psychological well-being enhanced performance. Research has documented certain personality factors that influence people's likelihood experiencing flow. However, the association between demographic variables flow proneness in various activities been less thoroughly explored existing findings are often inconsisten...

We consider polymatrix coordination games with individual preferences where every player corresponds to a node in a graph who plays with each neighbor a separate bimatrix game with non-negative symmetric payoffs. In this paper, we study α-approximate k-equilibria of these games, i.e., outcomes where no group of at most k players can deviate such that each member increases his payoff by at least...