OBJECTIVE
The aim of this study was to elucidate whether age plays a role in the expansion or regeneration of beta-cell mass.
RESEARCH DESIGN AND METHODS
We analyzed the capacity of beta-cell expansion in 1.5- and 8-month-old mice in response to a high-fat diet, after short-term treatment with the glucagon-like peptide 1 (GLP-1) analog exendin-4, or after streptozotocin (STZ) administration.
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