Combined discrete event and continuous views of production processes are important in designing computer control systems for both process industries and manufacturing. The paper presents an extension of the popular Matlab–Simulink simulation tool to facilitate the simulation of the discrete sequential control logic applied to continuous processes. The control system is modelled as a combined sy...

Sand production is considered as one of the significant issues that significantly reduce wellbore productivity. The process sand or solids in operations crucial operational inefficiencies can lead to wells collapsing. Besides, drilling mud might erupt through formation. Therefore, it essential properly determine what types are produced correctly predict efficient control mechanisms. This paper ...

The paper describes the possible roles of the simulation and emulation in production planning and scheduling as well as in production control systems through a casestudy for optimizing the internal logistic system of a given production system. In the study focuses on the control of a transportation unit and automated storage and retrieval system are focused on. A complex simulation study has be...

Reactive Oxygen Species (ROS) are known to cause oxidative damage to DNA, proteins and lipids. In addition, recent evidence suggests that ROS can also initiate signaling cascades that respond to stress and modify specific redox-sensitive moieties as a regulatory mechanism. This suggests that ROS are physiologically-relevant signaling molecules. However, these sensor/effector molecules are not u...

This paper is concerned witl). "a problem in which a firm is engaged in manufacturing a number of types and sizes of goods at equal intervals, e. g. monthly, and the production is forced to fulfill the customer's demand immediately. In general the products are subject to considerable variations in demands. Let us assume that the amount demanded is uncertain but has a certain probability distrib...

The manufacturing system environment is typically a complex system, involving many variables and constraints, being in certain cases a chaotic system. The introduction of new paradigms to face globalisation, distribution of activities and customer satisfaction requirements, increases the problem complexity. The new manufacturing control approaches should support the agile adaptation to volatile...

Immunoglobulin E (IgE) was the last discovered immunoglobulin class (in 1966). Having evolved from the same ancestral " IgY " gene duplicated in mammals 300 million years ago, IgG and IgE indeed followed very different careers with IgG now being the predominant serum Ig while IgE reaches levels 100,000-fold lower. In contrast, IgE became the most potent Ig, notably active against parasites, tox...