Multidisciplinary Design Optimization (MDO) is a design methodology that derives optimal design solutions by concurrently considering various mutually dependent design elements from an assortment of disciplines. As such, it is applicable to the designing of ships and automobiles, as well as to aero vehicles. However, applying MDOmethodologies in the real world would require a designer to spend ...

Expression of eukaryotic proteins in E. coli often results in their aggregation. Proper folding and solubility of therapeutical proteins are the pre-requisite for their bioactivity. This is not achieved in cytoplasmic expression in E. coli because of the absence of disulfide bonds formation. A novel expression/secretion vector was constructed which exploited β-lactamase signal sequence to trans...

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Extension is uniquely positioned to deliver data-driven solutions complex community issues with University applied research, particularly through crises like COVID-19. Applying the Policy, Systems and Environmental (PSE) framework development an effective, innovative approach in guiding leaders create, document, share long-term transformative change on challenging stakeholders. Beyond public he...

Requirements engineering (RE) is often seen as an essential facet in software development. It is a vital process before each project starts. In the context of systems engineering, an understanding and application of systems theory and practice is also relevant to RE. The contexts in which RE takes place habitually involve human activities. Therefore, RE needs to be sensitive to how people perce...