Numerous antiangiogenic agents are approved for the treatment of oncological diseases. However, almost all patients develop evasive resistance mechanisms against antiangiogenic therapies. Currently no predictive biomarker for therapy resistance or response has been established. Therefore, the aim of our study was to identify biomarkers predicting the development of therapy resistance in patient...

PURPOSE Thrombospondin-1 (Tsp1), endostatin, and tumstatin are extracellular matrix-associated proteins that inhibit angiogenesis. We examined the mechanisms by which tumor cells may bypass the antiangiogenic effects of these endogenous regulators. EXPERIMENTAL DESIGN CT26 colon and RenCa renal carcinoma cells were stably transfected with Tsp1, endostatin, or tumstatin cDNA. Subcutaneous and ...

Sphingosine 1-phosphate (S1P) is a potent lipid mediator that modulates inflammatory responses and proangiogenic factors. It has been suggested that S1P upregulates choroidal neovascularization (CNV) and may be deeply involved in the pathogenesis of exudative age-related macular degeneration (AMD). Recent studies have suggested that apolipoprotein M (ApoM), a carrier protein for S1P, modulates ...

Background: An estimated 37,340 new cases of thyroid cancer will be diagnosed in 2008. As high as Women will count for 75% of these new cases and over 50% of deaths from thyroid cancer. Although thyroid cancer has an excellent prognosis, an important subset is difficult to treat and radioresistant. Angiogenesis is critical for tumor growth. VEGF and IL8 are proangiogenic factors. S1P is a bioac...

Background: An estimated 37,340 new cases of thyroid cancer will be diagnosed in 2008. As high as Women will count for 75% of these new cases and over 50% of deaths from thyroid cancer. Although thyroid cancer has an excellent prognosis, an important subset is difficult to treat and radioresistant. Angiogenesis is critical for tumor growth. VEGF and IL8 are proangiogenic factors. S1P is a bioac...

It is well known that the metabolic factors play an important role in the regulation of angiogenesis. Increased metabolic activity leads to decreased oxygen levels and causes tissue hypoxia. Hypoxia starts different signals to stimulate angiogenesis and promotes oxygen delivery to tissues. It has been suggested that released adenosine from hypoxic tissues plays a vital role in angiogenesis. ...

TIE2-expressing monocytes/macrophages (TEM) are a highly proangiogenic subset of myeloid cells in tumors. Here, we show that circulating human TEMs are already preprogrammed in the circulation to be more angiogenic and express higher levels of such proangiogenic genes as matrix metalloproteinase-9 (MMP-9), VEGFA, COX-2, and WNT5A than TIE2(-) monocytes. Additionally, angiopoietin-2 (ANG-2) mark...

RATIONALE Proangiogenic hematopoietic and endothelial progenitor cells (EPCs) contribute to postnatal neovascularization, but the mechanisms regulating differentiation to the endothelial lineage are unclear. OBJECTIVE To elucidate the epigenetic control of endothelial gene expression in proangiogenic cells and EPCs. METHODS AND RESULTS Here we demonstrate that the endothelial nitric oxide s...

Stem cell therapy could be a promising option for the treatment of vascular diseases. The finding of stem/progenitor cells in circulating blood and the vessel wall indicates that endogenous (adult) stem cells have the ability to repair endothelial cells, thereby restoring the integrity of the vessel and most importantly its function. However, embryonic stem cells, which are a population of undi...