TMPRSS2/ERG rearrangement, PTEN gene deletion, and androgen receptor (AR) gene amplification have been observed in various stages of human prostate cancer. We hypothesized that using these markers as a combined panel would allow better differentiation between low-risk and high-risk prostate cancer. We analyzed 110 primary prostate cancer samples, 70 metastatic tumor samples from 11 patients, an...

Wood-based composite panels generally are first tested out-of-plane in the primary panel direction followed by the cross panel direction, but rarely edgewise. While most applications use wood-based composites in the flat-wise orientation and only need the out-of-plane properties, there are construction configurations where edgewise properties are needed for improved design configurations. A squ...

We have previously demonstrated that an improved affinity TCR generated against NYESO-1 has shown remarkable efficacy in clinical studies in multiple myeloma (NCT01352286). The same TCR is also being tested in synovial sarcoma (NCT01343043), melanoma (NCT01350401) and ovarian (NCT01567891) clinical trials. We will extend these clinical studies to include hepatocellular carcinoma shortly. In thi...

PURPOSE This manuscript presents evidence-based guidance on the use of vital pulp therapies for treatment of deep caries lesions in children. A guideline panel convened by the American Academy of Pediatric Dentistry formulated evidence-based recommendations on three vital pulp therapies: indirect pulp treatment (IPT; also known as indirect pulp cap), direct pulp cap (DPC), and pulpotomy. METH...

To identify genes associated with prostate cancer progression, we developed a strategy involving the use of differential display PCR and a panel of genetically matched primary tumor- and metastasis-derived mouse prostate cancer cell lines. We analyzed sequences that were differentially stimulated by transforming growth factor-beta1 in primary tumor-versus metastasis-derived cell lines, based on...

The efficacy of monoclonal antibody therapy depends in part on the expression of the relevant tumor-associated antigens by both primary tumors and their metastases. Antigen expression by paired primary and autologous metastases from surgically excised osteogenic and soft-tissue sarcomas from 15 patients was studied using a panel of murine hybridoma monoclonal antibodies and indirect immunoperox...

PURPOSE Patients with metastatic adenocarcinoma of unknown origin are a common clinical problem. Knowledge of the primary site is important for their management, but histologically, such tumors appear similar. Better diagnostic markers are needed to enable the assignment of metastases to likely sites of origin on pathologic samples. EXPERIMENTAL DESIGN Expression profiling of 27 candidate mar...

PURPOSE Primary care is the cornerstone of the health care system and increasingly countries are developing indicators for assessing quality in primary care practices. The 'Quality Tool', developed in Ontario, Canada, provides a framework for assessing practices and consists of indicators and criteria. The purpose of this study was to validate the indicators and simplify the Quality Tool. MET...

Introduction Direct primary care (DPC), a fee for membership type of practice, is an evolving innovative primary care delivery model. Little is known about current membership fees, insurance billing status, physician training, and patient panel size in DPC practices. This study aimed to obtain current data for these variables, as well as additional demographic and financial indicators, and rela...

The National Crime Victimization Survey (NCVS) began full-scale data collection in 1972. Over time, increasing costs of data collection and a diminishing budget have forced a gradual reduction of the sample size from 72,000 households in 1972 to 38,600 in 2005, leaving the NCVS far less able to meet its initial goals. The sponsor of the NCVS, the Bureau of Justice Statistics (BJS), asked a pane...