Perianal Paget's disease is a rare malignancy. It is rarely isolated and often associated with an underlying adenocarcinoma. It usually presents with anal itchiness and discomfort and can be misdiagnosed as hemorrhoids. Once the diagnosis of perianal Paget's disease is granted, extensive work-up to find an underlying primary malignancy is crucial. Surgery is the standard modality of treatment o...

Nonfocal liver biopsy may be required to diagnose or stage diffuse parenchymal dis• ease such as cirrhosis, viral hepatitis, autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, hemachromatosis, and Wilson’s disease. Focal liver biopsy may be necessary to diagnose or stage primary or secondary hepatic • malignancy and to differentiate malignancy from benign hepatic m...

rhabdomyosarcoma is a common primary childhood malignancy that rarely metastasizes to the breast. we report a patient with a primary sinonasal rhabdomyosarcoma metastasizing to the breast, with no distant spread. we describe the imaging appearance of rhabdomyosarcoma on magnetic resonance imaging (mri), particularly on diffusion-weighted imaging (dwi) and apparent diffusion coefficient (adc) se...

BACKGROUND Patients with head and neck cancer are at high risk for second primary malignancies. Human papillomavirus (HPV)-driven tumors are generally high-grade oropharyngeal cancers. We analyzed the incidence of second primary malignancy of the head and neck in patients with primary squamous cell carcinoma (SCC) of the head and neck and temporal trends in the HPV era. METHODS The Surveillan...

Retinoblastoma patients have a strongly increased risk of second malignancies, and survivors with a third or subsequent malignancy are increasingly observed. However, it has not been examined whether survivors who developed a second malignancy have a greater risk of a subsequent malignancy. On the basis of the Dutch retinoblastoma registry, the risk of a third malignancy was compared with cance...

OBJECTIVE We noticed that a significant proportion of our patients with head and neck mucoepidermoid carcinoma (HNMEC) had second primary malignancies. To our knowledge, such an association has never been described. The aim of our study is to elucidate the association between second primary malignancies and HNMEC. STUDY DESIGN Case series with chart review. SETTING Tertiary referral center....

  Primary non-Hodgkin lymphoma of liver is a very rare malignancy. Here we report a case of primary hepatic Burkitt’s lymphoma in a 34-year old man who was known case of acquired immunodeficiency syndrome (AIDS) and presented with weight loss, abdominal pain, and fever. Positive laboratory findings were mild anemia and elevated levels of lactate dehydrogenase (LDH) and alkaline phosphatase (AL...

BACKGROUND Thyroid cancer is one of the most common secondary cancers after treatment of malignancy in childhood or adolescence. Thyroid gland is very sensitive to the carcinogenic effect of ionizing radiation, especially in children. Imbalance between pro- and anti-oxidant factors may play a role in thyroid carcinogenesis. Our study aimed to assess the relationship between genetic variability ...

second primary malignancy following multiple myeloma (mm) was reported several years ago. there are also rare reports of cases with synchronous mm and other malignancies. to our knowledge, only one case of mm following bladder cancer has been reported in the literature. here, we report the second case occurred three months after diagnosis of bladder cancer.

Sister Mary Joseph's nodule is sometimes the first sign of an internal malignancy, including gastrointestinal, gynecological, or malignancy of unknown primary. It is rarely the sole presentation of a primary peritoneal cancer. In this report, we present the case of a 70-year-old female with umbilical drainage and a computed tomography scan consistent with solitary umbilical nodule. Excision of ...