BACKGROUND Primary localized cutaneous amyloidosis (PLCA) is a chronic pruritic dermatological disorder of unknown aetiology. Genetic mutations in cases of familial PLCA have been mapped to the oncostatin-M receptor (OSMR) β, a subunit of interleukin (IL)-31 receptor. IL-31 has been implicated in the pathogenesis of atopic dermatitis (AD). OBJECTIVES To assess if AD is more prevalent in patie...

The term primary cutaneous amyloidosis (PCA) refers to a group of diseases caused by the extracellular deposition of amyloid in the skin without the involvement of other organs. PCA has been divided into the following types: macular, lichen and nodular. The first 2 types are characterized by the deposition in the papillary dermis of amyloid derived from the degeneration of keratin filaments. Pr...

Amyloidosis, a heterogenous group of disorders, is characterized by the extracellular deposition autologous, insoluble, fibrillar misfolded proteins. These proteins deposit in tissues aggregated s-pleated sheets arranged an antiparallel fashion and cause distortion to tissue architecture function. In current literature, about 60 heterogeneous amyloidogenic have been identified, out which 27 ass...

Apolipoprotein E (apoE) is a lipid transport protein, which is a component of lipoproteins, such as very low density lipoprotein, intermediate density lipoprotein, high density lipoprotein, and chylomicron. ApoE is also produced and secreted in the skin, and is implicated to play roles in epidermal differentiation and proliferation (Barra et al, 1994). We have reported that apoE was a component...

Primary localized cutaneous amyloidosis (PLCA) is a relatively rare condition characterized by amyloid de-position exclusively in the dermis without involving the internal organs. Clinically, papular, macular and tumefac-tive forms are presented. Although PLCA may sometimes overlap with collagen vascular diseases, association with scleroderma is rare. We report here two cases of PLCA developing...

Amyloidosis of the gastrointestinal tract is usually a systemic disease. Localized gastrointestinal amyloidosis without evidence of extraintestinal involvement or an associated plasma cell dyscrasia is uncommon and does not usually cause death. We report a case of a patient with localized gastrointestinal amyloidosis who presented with protein-losing enteropathy and a fatal upper gastrointestin...

Purpose: We report a young patient with unilateral eyelid swelling secondary to local, palpebral conjunctival amyloidosis.Case summary: A 31-year-old male was referred 6-month history of mild, right upper but without redness or tenderness. Slit-lamp examination revealed diffuse hemorrhagic papilliform lesion on the conjunctiva, this raised suspicion giant papillary conjunctivitis. As unilateral...

Primary pulmonary amyloidosis is an uncommon manifestation, characterized by amyloid deposition in the lungs and other associated tissue. The clinical presentation of amyloidosis is variable, with non-specific symptoms. The current study reports the case of a 59-year-old female presenting with primary pulmonary amyloidosis, indistinguishable from lung malignancy based on 18F-fluoro-deoxyglucose...