نتایج جستجو برای: primary and metastatic melanoma

تعداد نتایج: 16947239  

2016
Birgit Schütz Anita Koppensteiner David Schörghofer Katharina Kinslechner Gerald Timelthaler Robert Eferl Markus Hengstschläger Albert Missbichler Harald Hundsberger Mario Mikula

Melanoma is the most aggressive type of skin cancer and one of the most frequent tumours in young adults. Identification of primary tumours prone to develop metastasis is of paramount importance for further patient stratification. However, till today, no markers exist that are routinely used to predict melanoma progression. To ameliorate this problem, we generated antiserum directed against met...

2011
Tobias Sinnberg Moritz Menzel Daniel Ewerth Birgit Sauer Michael Schwarz Martin Schaller Claus Garbe Birgit Schittek

Beta-catenin plays an important role in embryogenesis and carcinogenesis by controlling either cadherin-mediated cell adhesion or transcriptional activation of target gene expression. In many types of cancers nuclear translocation of beta-catenin has been observed. Our data indicate that during melanoma progression an increased dependency on the transcriptional function of beta-catenin takes pl...

2010
Omar Kabbarah Cristina Nogueira Bin Feng Rosalynn M. Nazarian Marcus Bosenberg Min Wu Kenneth L. Scott Lawrence N. Kwong Yonghong Xiao Carlos Cordon-Cardo Scott R. Granter Sridhar Ramaswamy Todd Golub Lyn M. Duncan Stephan N. Wagner Cameron Brennan Lynda Chin

A cardinal feature of malignant melanoma is its metastatic propensity. An incomplete view of the genetic events driving metastatic progression has been a major barrier to rational development of effective therapeutics and prognostic diagnostics for melanoma patients. In this study, we conducted global genomic characterization of primary and metastatic melanomas to examine the genomic landscape ...

Journal: :Oncotarget 2016
Denis Shepelin Mikhail Korzinkin Anna Vanyushina Alexander Aliper Nicolas Borisov Raif Vasilov Nikolay Zhukov Dmitry Sokov Vladimir Prassolov Nurshat Gaifullin Alex Zhavoronkov Bhupinder Bhullar Anton Buzdin

Melanoma is the most aggressive and dangerous type of skin cancer, but its molecular mechanisms remain largely unclear. For transcriptomic data of 478 primary and metastatic melanoma, nevi and normal skin samples, we performed high-throughput analysis of intracellular molecular networks including 592 signaling and metabolic pathways. We showed that at the molecular pathway level, the formation ...

Journal: :Cancer research 1986
D Taramelli G Fossati A Mazzocchi D Delia S Ferrone G Parmiani

Human melanoma cells freshly isolated from 20 patients with primary and 73 patients with metastatic melanomas were analyzed by indirect immunofluorescence staining with monoclonal antibodies (MoAb) to class I (HLA-A, -B, and -C) and class II (HLA-DR and -DQ) antigens and to melanoma associated antigen (MAA). The latter included the GD3-MAA and the high molecular weight MAA. HLA class I antigens...

2017
Siqi Wang Wenliang Fan Bing Wan Mengqi Tu Feng Jin Fang Liu Haibo Xu Ping Han

The incidence of melanoma, the most aggressive and life-threatening form of skin cancer, has significantly risen over recent decades. Therefore, it is essential to identify the mechanisms that underlie melanoma tumorigenesis and metastasis and to explore novel and effective melanoma treatment strategies. Accumulating evidence s uggests that aberrantly expressed long noncoding RNAs (lncRNAs) hav...

2011
Umair Khalid Taimur Saleem Ayesha Mallick Imam Muhammad Rizwan Khan

BACKGROUND Melanomas within the alimentary tract are usually metastatic in origin. On the other hand, primary melanomas of the gastrointestinal tract are relatively uncommon. There are several published reports of melanomas occurring in the esophagus, stomach, small bowel, and anorectum. The occurrence of primary melanoma of the colon has, however, only been rarely reported. The optimum modus o...

2009
Aaron R. Jeffs Amy C. Glover Lynn J. Slobbe Li Wang Shujie He Jody A. Hazlett Anshul Awasthi Adele G. Woolley Elaine S. Marshall Wayne R. Joseph Cristin G. Print Bruce C. Baguley Michael R. Eccles

BACKGROUND We are investigating the molecular basis of melanoma by defining genomic characteristics that correlate with tumour phenotype in a novel panel of metastatic melanoma cell lines. The aim of this study is to identify new prognostic markers and therapeutic targets that might aid clinical cancer diagnosis and management. PRINCIPAL FINDINGS Global transcript profiling identified a signa...

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