BACKGROUND There is much interest in ultra-short alcohol screening in primary care that may support brief alcohol interventions. Brief screening consisting of one or two questions might be used alone or in combination with longer tests as recommended by the Primary Care Service Framework. AIM To investigate whether a simple one and two question screening might prove an accurate and acceptable...

• Objective: To examine the rationale and evidence to support pharmacotherapies to treat alcohol problems in the primary care setting. • Methods: Qualitative review of the literature. • Results: Problem alcohol consumption is a prevalent problem in the United States and results in significant morbidity and mortality. In recent years, new pharmacologic treatments have been approved by the U.S. F...

BACKGROUND The association between harmful use of alcohol and HIV infection is well documented. To address this dual epidemic, the US President's Emergency Plan for AIDS Relief (PEPFAR) developed and implemented a multi-pronged approach primarily in Namibia and Botswana. We present the approach and preliminary results of the public health investigative and programmatic activities designed, init...

OBJECTIVE To evaluate the efficacy and relative costs of different screening methods for the identification of alcohol use disorders in an opportunistic screening programme in primary care in the United Kingdom. DESIGN Comparative study. SETTING Six general practices in south Wales. PARTICIPANTS 194 male primary care attendees aged 18 or over who completed an alcohol use disorders identif...

a direct and an efficient conversion of a wide range of primary, secondary even tertiary alcohols to the corresponding iodides have been achieved under ionic liquid conditions. the method involves preparation of ionic liquid-based iminium chloride intermediate from dmf-like ionic liquid then stirring it with alcohol in present of sodium iodide. the higher yields of alkyl iodides were obtained w...

BACKGROUND There is a wealth of evidence regarding the detrimental impact of excessive alcohol consumption. In older populations excessive alcohol consumption is associated with increased risk of coronary heart disease, hypertension, stroke and a range of cancers. Alcohol consumption is also associated with an increased risk of falls, early onset of dementia and other cognitive deficits. Physio...

OBJECTIVE To identify patient factors associated with primary care physicians asking about alcohol consumption, warning of harmful ethanol effects, and advising modification of alcohol use in their patients. METHOD A cross-sectional design was used, with a probability sample of 1,333 adult family medicine patients, stratified by sex and racial/ethnic background, drawn from a university-based,...

BACKGROUND The leading mental health causes of the global burden of disease are depression in women and alcohol use disorders in men. A major hurdle to the implementation of evidence-based psychological treatments in primary care in developing countries is the non-availability of skilled human resources. The aim of these trials is to evaluate the effectiveness and cost-effectiveness of two psyc...

OBJECTIVE To examine the National Institute on Alcohol Abuse and Alcoholism Youth Guide alcohol frequency screening thresholds when applied to Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) diagnostic criteria, and to describe alcohol use patterns and alcohol use disorder (AUD) characteristics in rural youth from primary care settings. STUDY DESIGN Adolescents (n =...

BACKGROUND Topiramate increases GABAergic activity and antagonizes the AMPA/kainate subtype of glutamate receptors. Through these mechanisms of action, topiramate may reduce alcohol and cocaine reward and may reduce alcohol and cocaine craving. Topiramate has been shown to reduce drinking in persons with alcohol dependence, and reduce relapse in stimulant-dependent patients. The current trial w...