Machine Learning algorithms have a variety of important applications, and among them, Recommender systems are crucial. The internet hosts an extensive volume information, making it challenging for users to navigate find relevant content. therefore emerged as valuable tools bridge this gap. They facilitate the connection between content by offering personalized recommendations. In recent years r...

Untargeted mutation and delayed mutation are features of radiation-induced genomic instability and have been studied extensively in tissue culture cells. The mouse pink-eyed unstable (p(un)) mutation is due to an intragenic duplication of the pink-eyed dilution locus and frequently reverts back to the wild type in germ cells as well as in somatic cells. The reversion event can be detected in th...

A cohort of 123 adult contacts was followed for 18-24 months (86 completed the follow-up) to compare conversion and reversion rates based on two serial measures of QuantiFERON (QFT) and tuberculin skin test (TST) (PPD from TUBERSOL, Aventis Pasteur, Canada) for diagnosing latent tuberculosis (TB) in household contacts of TB patients using conventional (C) and borderline zone (BZ) definitions. Q...

In most organisms, the mismatch repair (MMR) system plays an important role in substantially lowering mutation rates and blocking recombination between nonidentical sequences. In Saccharomyces cerevisiae, the products of three genes homologous to Escherichia coli mutS-MSH2, MSH3, and MSH6-function in MMR by recognizing mispaired bases. To determine the effect of MMR on single-base pair mismatch...

Light-oxygen-voltage (LOV) domains function as blue light-inducible molecular switches. The photosensory LOV domains derived from plants and fungi have provided an indispensable tool for optogenetics. Here we develop a high-throughput screening system to efficiently improve switch-off kinetics of LOV domains. The present system is based on fluorescence imaging of thermal reversion of a flavin c...

Understanding the changes of activated HSCs reversion is an essential step toward clarifying the potential roles of HSCs in the treatment of liver fibrosis. In this study, we chose adipocyte differentiation mixture to induce LX-2 cells for 2 days in vitro as reversion phase, comparing with normal cultured LX-2 cells as activation phase. Mass spectrometric-based SILAC technology was adopted to s...

The interest in using the pseudoelastic properties of NiTi wires in orthodontic practice arises chiefly from the expectation that they can afford low continuous forces at constant temperature. The reversion force developed by NiTi archwires depends, however, upon temperature since the superelastic force follows a Clausius-Clapeyron like equation. Actually the oral environment temperature is mod...

In the dynamic world of financial markets, prices assets can exhibit dramatic fluctuations, sometimes soaring to dizzying heights or plummeting alarming lows. However, amidst chaos, a fascinating phenomenon emerges: tendency for revert back their long-term average mean level. This concept known as reversion has intrigued traders, investors, and researchers decades. Understanding provides valuab...

Sindbis vectors have shown remarkable antitumor efficacy and tumor-targeting capacity in animal models and hold promise for cancer therapy. Different packaging systems are used to produce propagation-incompetent Sindbis vectors. However, the vectors produced using either DH-BB single helper RNA or split helper RNA can spread in permissive cell cultures. We investigated the mechanisms of vector ...

The relationship between the Tibetan prelate Tāranātha (1575-1634) and his major patrons, the various sDe pa of gTsang is a most complex one. In studying it I am increasingly aware that the wealth of detail to be gleaned from the various relevant texts is not just limited to the narrow study of the lives of just a few people, in this case those of Tāranātha and the various rulers of gTsang. Ind...