In oncology, combinations of drugs are often used to improve treatment efficacy and/or reduce harmful side effects. Dual-agent phase I clinical trials assess drug safety and aim to discover a maximum tolerated dose combination via dose-escalation; cohorts of patients are given set doses of both drugs and monitored to see if toxic reactions occur. Dose-escalation decisions for subsequent cohorts...

Question: A 46-year-old woman presented to the emergency department with a 1-day history of sudden onset colicky central abdominal pain. She had been passing flatus until that morning and her last bowel motion was day before. tolerating diet without any nausea or vomiting. no significant medical otherwise previously fit well throughout life. previous surgery endoscopic procedures. an active smo...

In many cases self-calibration is not able to yield a unique solution for the 3D reconstruction of a scene. This is due to the occurrence of critical motion sequences. If this is the case, an ambiguity is left on the reconstruction. In this paper it is derived under which conditions correct novel views can be generated from ambiguous reconstructions. The problem is first approached from a theor...

Several affective and cognitive processes have been found to be pivotal in affecting aesthetic experience of artworks and both neuropsychological as well as psychiatric symptoms have been found to affect artistic production. However, there is a paucity of studies directly investigating effects of brain lesions on aesthetic judgment. Here, we assessed the effects of unilateral brain damage on ae...

Supervised polarity classification systems are typically domain-specific. Building these systems involves the expensive process of annotating a large amount of data for each domain. A potential solution to this corpus annotation bottleneck is to build unsupervised polarity classification systems. However, unsupervised learning of polarity is difficult, owing in part to the prevalence of sentime...