We developed a laboratory model of a unit of hemopoietic progenitor cells (mock-HPC unit) suitable for the validation of HPC cryopreservation procedures. The project was prompted by the practical and ethical difficulty of using real HPC units collected from healthy donors and patients for validation purposes. Mock-HPC units of different volumes ranging from about 120 to about 540mL were prepare...

We have recently demonstrated that tumor necrosis factor alpha (TNF-alpha) potentiates interleukin 3 (IL-3) and granulocyte/macrophage colony-stimulating factor-induced growth of CD34+ hematopoietic progenitor cells (HPC), and favors the generation of dendritic/Langerhans cells. The stimulatory effect of TNF-alpha was detailed in the present study. Thus, CD34+ HPC entering in cycle (S/G2M) afte...

OBJECTIVE AMP-activated protein kinase (AMPK) is an important regulator of multiple cellular pathways in the setting of energetic stress. Whether AMPK plays a critical role in hypoxic preconditioning (HPC), protecting cardiomyocytes against hypoxia reoxygenation (H/R) injury remains uncertain. METHODS H9c2 cells were preconditioned by exposing to 10 min of hypoxia and 30 min of reoxygenation....

PURPOSE The purpose of this study was to evaluate the prevalence of and relationship between hypomineralized second primary molars (HSPM) and hypomineralized primary canines (HPC) with molar-incisor hypomineralization (MIH) in 1,963 schoolchildren. METHODS The European Academy of Paediatric Dentistry (EAPD) criterion was used for scoring HSPM/HPC and MIH. Only children with four permanent fir...

High-Performance Computing (HPC) and the ability to process large amounts of data are of paramount importance for UK business and economy as outlined by Rt Hon David Willetts MP at the HPC and Big Data conference in February 2014. However there is a shortage of skills and available training in HPC to prepare and expand the workforce for the HPC and Big Data research and development. Currently, ...

Since deployment, our HPC environment has supported a 13x increase in compute demand, with a 10x increase in stability. In addition, tapeout time was reduced from 25 days for the first 65-nm process technologybased microprocessor in a non-HPC compute evironment to 10 days for the first 45-nm process technology-based microprocessor in an HPC-enabled envirnoment. The success of the HPC environmen...

We examined whether repeated reactivations of a context memory would prevent the typical amnesic effects of post-training damage to the hippocampus (HPC). Rats were given a single contextual fear-conditioning session followed by 10 reactivations, involving a brief return to the conditioning context (no shock). Subsequently, the rats received sham or complete lesions of the HPC. When tested for ...

BACKGROUND Solitary Fibrous Tumours (SFT) and haemangiopericytomas (HPC) are rare meningeal tumours that have to be distinguished from meningiomas and more rarely from synovial sarcomas. We recently found that ALDH1A1 was overexpressed in SFT and HPC as compared to soft tissue sarcomas. Using whole-genome DNA microarrays, we defined the gene expression profiles of 16 SFT/HPC (9 HPC and 7 SFT). ...

A bridge is a structure providing passage over an obstacle without closing the way beneath. The required passage may be for a road, a railway, pedestrians, a canal or a pipeline. Now a days, bridge deck section of Box shapes are used widely. Most of the bridges constructed are of Box girders. Method of post-tensioning in the construction of bridges is very common today. Most of the bridges are ...

Stainless steel reinforcing has an elevated chloride threshold and is an attractive alternative for prestressed concrete applications. However, due to the high strength requirements for prestressing strands, concern exists about the possibility of stress corrosion cracking (SCC). This investigation screened for potential SCC development three candidate high strength alloys for use as prestresse...