نتایج جستجو برای: prepulse inhibition
تعداد نتایج: 328339 فیلتر نتایج به سال:
CONTEXT Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia. OBJECTIVE To characterize the genetic architecture of some key endophenotypic measures selected for their reported heritabilities in schizophrenia. DESIGN Family-based heritability study. SETTING Seven sites across the United States. ...
Abstract The influences of smoking status and schizotypy on prepulse inhibition (PPI) of the startle eye-blink response were assessed in 71 healthy volunteers, across a wide range of prepulse-to-pulse intervals (50-2020 ms). Multiple regression analyses revealed that nonsmoking participants high in cognitive disorganization showed reduced PPI between 50 and 260 ms, whereas at prepulse intervals...
A measure of auditory prepulse inhibition (PPI) is the reduction of the scalp-recorded P1 event-related potential (ERP) after a sound that is preceded by 100-300 ms by a click as prepulse. This measure of sensory gating was adapted to study the effect of a prepulse on processing tones that were part of a 'go no-go' discrimination. ERPs were recorded at right and left, frontal and temporal sites...
Prepulse inhibition (PPI) of the startle response refers to a reduction in response to a strong stimulus (pulse) if this is preceded shortly by a weak non-startling stimulus (prepulse). Consistent with theories of deficiencies in early stages of information processing, PPI is found to be reduced in patients with schizophrenia. Atypical antipsychotics are found to be more effective than typical ...
Prepulse inhibition (PPI) is typically associated with an attenuation of auditory startle behavior in mammals and is presumably mediated within the brainstem startle circuit. However, the inhibitory mechanisms underlying PPI are not yet clear. We addressed this question in behavioral and complementary in vivo electrophysiological experiments in the startle escape circuit of goldfish, the Mauthn...
Perceptual learning (training-induced performance improvement) can be elicited by task-irrelevant stimulus exposure in humans. In contrast, task-irrelevant stimulus exposure in animals typically disrupts perception in juveniles while causing little to no effect in adults. This may be due to the extent of exposure, which is brief in humans while chronic in animals. Here we assessed the effects o...
Attention and prepulse inhibition: the effects of task-relevant, irrelevant, and no-task conditions.
We investigated whether attentional modulation of prepulse inhibition (PPI) is due to increased protection of processing of attended lead stimuli, decreased protection of processing of ignored lead stimuli, or a combination of both processes. Task and no-task trials, pre-cued by red and blue dots on a computer screen, were randomly intermixed. College student participants were instructed to do ...
We examined whether monaural prepulses produce more prepulse inhibition (PPI) because they might be more attention capturing (unambiguous to locate) than binaural prepulses. Monaural and binaural PPI was tested under normal and verbal and visuospatial attention manipulation conditions in 55 healthy men, including 29 meditators. Attention manipulations abolished monaural PPI superiority, similar...
Young adult and aged F344 rats were compared on a silent gap variant of the prepulse inhibition paradigm. Animals were tested using a 50-ms single tone cue, followed by 8 days of silent gap testing. The first 3 days of gap testing were long gaps (range 2 to 100 ms) followed by 5 days of short gaps (range 2 to 10 ms). The effects of gap length, prior experience, and age, on the magnitude and dir...
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