An uncatalyzed and easily accessible synthetic approach for the preparation of 3-aroylindoles was investigated using nitrosoarenes aromatic terminal ethynyl ketones. Indole derivatives were produced in good yields excellent regioselectivity. Functionalizations indole products carried out affording highly valuable versatile compounds. The indolization protocol studied as a fundamental step prava...

2-amino-substituted ketones react with α-methylene ketones under solvent-free conditions at 90 °c in thepresence of a catalytic amount of zirconium dodecylphosphonate to create the corresponding quinolinesin excellent yields. this procedure recommends numerous advantages such as easy work-up, use of mild,reusable and safe catalyst, short reaction timeand high yields. the new compounds have been...

BACKGROUND A new and efficient method have been developed for the synthesis of different indole derivatives from various ketones, having at least one hydrogen atom attached to each of their α-carbon atoms, and hydrazines in solvent-free conditions, using marine sponge/H3PO4 as a naturally occurring chiral catalyst. OBJECTIVES This study recommended the use of marine sponge/H3PO4 as a naturall...

A one-pot, three-step protocol for the preparation of Grignard reagents from organobromides in a ball mill and their subsequent reactions with gaseous carbon dioxide (CO2) or sodium methyl carbonate providing aryl alkyl carboxylic acids up to 82 % yield is reported. Noteworthy are short reaction times significantly reduced solvent amounts [2.0 equiv. liquid assisted grinding (LAG) conditions]. ...

Gem-dihydroperoxides as nearly stable peroxidic derivatives of aldehydes and ketones are known important intermediates in synthesis of anti-malaria drugs. Also, because containing high concentration of peroxidic oxygen, recently, some of these compounds have been used as solid, efficient and powerful oxidants in many oxidation organic reactions. Generally, these compounds are synthesiz...