This research includes synthesis of new derivatives benzimidazole , the compound (A1*) prepared by reaction o-phenylene diamine with carbon disulfide in alcoholic potassium hydroxide. Then was ethyl chloroacetate and hydroxide to give ester (A2*). preparation hydrazide (A3*) (A2*) hydrazine hydrate (80%). we used prepare pyrazole (A4), then mannich basses (A4) different primary aromatic amines ...

Hydrogels are commonly used as scaffolds for the preparation of three-dimensional tissue constructs and encapsulation delivery cells in regenerative medicine. Polyesters an attractive class polymers hydrogel preparation. However, most polyesters have hydrophobic backbones lack pendent groups that can be chemically functionalized. We describe here development water-soluble based on aspartic acid...

Amides are one of the most important functional groups in organic chemistry and play essential roles both pharmaceutical industry life sciences. However, due to natural reactivity carboxylic acids amines, their direct coupling is challenging often leads reactions that not atom-economic produce large amounts non-recoverable by-products. Despite impressive number reagents available, sustainable m...

Herein, we present a novel one-pot aqueous reaction for the synthesis of 2-iminothiazolines and 2-aminothiazoles using isocyanides, amines, sulfur, 2′-bromoacetophenones. The three-component preparation thioureas is followed by cyclization leading to heterocyclic product. This efficient mild procedure features excellent step- atom-economy enables chromatography-free diversely substituted 2-imin...

We have introduced a selective synthesis of tertiary amines using alkyl halide and ammonium salts as the amine sources in water. This green process has outstanding superiorities, such as being eco-friendly, possessing ammonium salts, and using water as a green solvent in the absence of organic ligands or catalysts. It is worth mentioning that the presence of t-Butyl alcohol and potassi...

1. The isolation, characterization and properties of two by-products in the preparation of 2-acetamido-3,4,6-tri-O- acetyl-2-deoxy-beta-d-glucopyranosylamine are described. They are bis(2-acetamido-2-deoxy-d-glucopyranosyl)amines. 2. An independent synthesis of the bis-glycopyranosylamines is reported and conditions are given for their preparation in high yield. 3. Further improvements are give...