The effect of pregnancy on seizure frequency was monitored prospectively in 136 pregnancies of 122 epileptic women. Pregnancy did not influence the seizure frequency in 68 pregnancies (50%). In 50 pregnancies (37%) the number of seizures increased during pregnancy or puerperium. The seizure frequency decreased in 18 pregnancies (13%). In 34 out of 50 pregnancies (68%) the increase was associate...

In preeclampsia, maternal insulin resistance leads to defective expansion of adipocytes, enhanced adipocyte lipolysis, up-regulation of very low density lipoprotein synthesis, maternal hypertriglyceridaemia and the potential for ectopic fat storage. Our aim was to quantitate and compare the total amount and type of lipid in placenta from pregnancies complicated with preeclampsia and healthy pre...

A monochorionic twin pregnancy is one in which both babies are dependent on a single, shared placenta. Around one-third of twin pregnancies in the UK have monochorionic placentas. Monochorionic placentation can also occur in higher-order multiples. There has been a recent increase in all types of multiple pregnancies with the increasing use of assisted reproductive techniques. Monochorionic (MC...

BACKGROUND To examine whether maternal serum levels of müllerian-inhibiting substance (MIS) differ in Down's syndrome and unaffected pregnancies. METHODS Case-control study was conducted using stored serum from an antenatal screening programme. Sera from 25 Down's syndrome pregnancies were retrieved from -20 degrees C storage together with 125 unaffected controls individually matched for mate...

Cohort studies of adverse reproductive effects of occupational exposures that compare the outcome of exposed pregnancies with non-exposed pregnancies among the same group of mothers (internal controls) and among a different group of mothers (external controls) have been reviewed. Confounding of the hypothesised associations by parental characteristics, the outcome of previous pregnancies, and o...