Functional neuroimaging in human subjects and studies of monkeys with lesions limited to the mid-dorsolateral (MDL) prefrontal cortex have shown that this specific region of the prefrontal cortex is involved in visual working memory, although its precise role remains a matter of debate. The present study compared the effect on visual working memory of lesions restricted to the mid-dorsolateral ...

The prefrontal cortex (PFC) is thought to control activity in the noradrenergic locus coeruleus (LC). Prior anatomical and stimulation studies demonstrated potential for PFC-LC interactions; however, it unknown what types of PFC affect LC. Here, we show that transient increases high ? power associated changes unit-pair synchrony are a sign top-down over

The dorsolateral prefrontal cortex and posterior parietal cortex have been implicated in the planning of movements and inhibition of inappropriate responses, though their precise roles in these functions are not known. To address this question, we trained monkeys to perform memory-guided saccade and anti-saccade tasks and compared neural responses in the same animals. A population of neurons wi...

It is now common to apply functional magnetic resonance imaging explore which areas of the human brain are activated during decision-making process. In study consumer behaviors, product brand has been identified as a major factor affecting purchase decisions. Prior studies indicate that had significant impact on activation. However, it unsure if consumers’ activation also when purchasing brand-...

Attentional set-shifting and discrimination reversal are sensitive to prefrontal damage in the marmoset in a manner qualitatively similar to that seen in man and Old World monkeys, respectively (Dias et al., 1996b). Preliminary findings have demonstrated that although lateral but not orbital prefrontal cortex is the critical locus in shifting an attentional set between perceptual dimensions, or...

Behavioral flexibility is the hallmark of goal-directed behavior. Whereas a great deal is known about the neural substrates of behavioral adjustment when it is explicitly cued by features of the external environment, little is known about how we adapt our behavior when such changes are made on the basis of uncertain evidence. Using a Bayesian reinforcement-learning model and fMRI, we show that ...

The orbital prefrontal cortex is thought to be involved in behavioral flexibility in primates, and human neuroimaging studies have identified orbital prefrontal activation during episodic memory encoding. The goal of the present study was to ascertain whether deficits in strategy implementation and episodic memory that occur after ablation of the entire prefrontal cortex can be ascribed to dama...

Research has suggested that aging results in a "positivity effect," with young adults dwelling on negative information, and older adults attending to positive information. In order to understand age-related changes in emotional processing underlying this effect, the present fMRI study compared neural activity in young and older adults as they viewed positive, negative, and neutral images. Resul...

Functional neuroimaging studies have demonstrated preferential involvement of bilateral prefrontal cortex during episodic memory encoding and retrieval. The aim of the present study is to address the question whether left prefrontal model for encoding holds when highly non-verbal material is used, and which region of the brain is critically related to successful retrieval. To do this, seven nor...

traumatic brain injury (tbi) is a common injury leading to child disability and is associated with a variety of long-term cognitive, social, and behavioral dysfunctions. emotion perception (ep) starts up an integral part of social communication is critical to achieve developmentally appropriate goals. this skill, which emerges relatively early in development, is driven by increasing connectivit...