Aggregates. For aggregates, we build on ideas in (Pelov 2004). We only consider decomposable aggregate functions, i.e., aggregates for which agg(S) = agg({agg(S′), agg(S \S′)}), for sets of domain elements S and S′ ⊂ S. Our transformation of agg({x ∈ T : φ : t}) is based on the decomposability of the considered aggregates and the fact that there is a total order on all domain elements, with a f...

BACKGROUND There is no agreement on how a bronchodilator response should be expressed. Ideally, the index used should be able to distinguish asthma from chronic obstructive lung disease and be independent of initial FEV1. METHODS Two hundred and seventy four adults (aged 18-60 years) outpatients with obstructive airways disease were studied. Patients were divided into syndrome groups on the b...

e-Table 1. Comparison of pulmonary function test results between Af-IgE-sensitized and non-IgEsensitized patients. Results are represented as mean ± SD, except for Raw %pred, where median (IQR) is used. p-values for multivariate analysis with age, gender, BMI, P. aeruginosa colonization, pancreatic insufficiency and gastro-esophageal reflux disease as covariates are given. n = number of patient...

The ability to predict immunogenic regions in selected proteins by in-silico methods has broad implications, such as allowing a quick selection of potential reagents to be used as diagnostics, vaccines, immunotherapeutics, or research tools in several branches of biological and biotechnological research. However, the prediction of antibody target sites in proteins using computational methodolog...

The single breath diffusing capacity of the lung for carbon monoxide (Dsb) was measured using three equations to describe CO uptake separately during inhalation, breath holding, and exhalation in 24 patients with cystic fibrosis and 30 control subjects with similar age and height distributions. Using the control group, we developed two prediction equations for Dsb: one based on height, age, and...

The aim of this study was done to assess the association of lung function with insulin resistance (IR), systemic inflammation, and metabolic syndrome (MetS). In 9,581 apparently healthy non-smoking male adults, pulmonary function, fasting glucose, insulin, lipid profiles and serum high-sensitivity C-reactive protein (hs-CRP) levels were measured, and homeostatic model assessment (HOMA) was used...

We define predictive information I(pred)(T) as the mutual information between the past and the future of a time series. Three qualitatively different behaviors are found in the limit of large observation times T:I(pred)(T) can remain finite, grow logarithmically, or grow as a fractional power law. If the time series allows us to learn a model with a finite number of parameters, then I(pred)(T) ...