Virus load and liver damage, as measured by quantitative polymerase chain reaction and histology activity index, were related to genotype and core promoter mutations in 43 chronic hepatitis B virus (HBV) carriers of East Asian origin. T-1762 mutants were more frequent in genotype C strains and were associated with more inflammation (P=.0036) and fibrosis (P=.0088) of the liver but not with hepa...

Multichoice games have been introduced by Hsiao and Raghavan as a generalization of classical cooperative games. An important notion in cooperative game theory is the core of the game, as it contains the rational imputations for players. We propose two definitions for the core of a multichoice game, the first one is called the precore and is a direct generalization of the classical definition. ...

INTRODUCTION The objectives of this study were evaluate hepatitis B virus (HBV) serological markers in children and adolescents followed up at the Child Institute of the Hospital das Clínicas, Faculdade de Medicina de São Paulo, Universidade de São Paulo; identify chronic HBV carriers and susceptible individuals in the intrafamilial environment; characterize HBV genotypes; and identify mutation...

The aim of this study was to explore the relationship between hepatitis B virus (HBV) core antigen (HBc) mutations and the post-operative prognosis of HBV-related hepatocellular carcinoma (HCC). In total, 98 patients suffering from HBV-related HCC and treated with surgery were enrolled, with a 48 month follow-up. The preCore/Core region of the HBV genome from tumour tissue (TT) and paired adjac...

We report a case of a precore mutant hepatitis B virus (HBV) reactivation in a patient with follicular lymphoma who was treated simultaneously with chemotherapy (cyclophosphamide, vincristine and prednisone) and rituximab, occurred five months after the end of therapy. Despite lamivudine therapy, she died because of fulminant hepatitis. This case illustrates the possibility of late reactivation...

A recent report of an outbreak investigation in this journal (1) explored the heterogeneity of variability across the hepatitis B virus (HBV) genome. As expected, genomic regions encoding a single gene product tended to be more variable than overlapping open reading frames (ORFs) with multiple translated products. The investigators recommend the use of the most rapidly evolving regions, such as...

Hepatitis B virus (HBV), a small and economically packaged double-stranded DNA virus, represents an enormous global health care burden. In spite of an effective vaccine, HBV is endemic in many countries. Chronic hepatitis B (CHB) results in the development of significant clinical outcomes such as liver disease and hepatocellular carcinoma (HCC), which are associated with high mortality rates. H...