Peroxisome proliferator activated receptor (PPAR) alpha is a member of the nuclear receptor superfamily that regulates key proteins involved in fatty acid oxidation, extracellular lipid metabolism, hemostasis, and inflammation. A L162V polymorphism at the PPARA locus has been associated with alterations in lipid and apolipoprotein concentrations. We studied the association among lipids, lipopro...

The purpose of this work was to study whether rat lactating mammary gland can synthesize PUFAs through the expression of D5 and D6 desaturases (D5D and D6D), whether these enzymes are regulated by the transcription factors sterol-regulatory element binding protein 1 (SREBP-1) and peroxisome proliferator-activated receptor a (PPARa) and the coactivator peroxisome proliferator-activated receptor ...

Abstract Background The human circadian clock is present in cells throughout the body. It consists of CLOCK and BMAL1 that heterodimerize bind to E-box sequences mediate transcription a large number genes, including Periods (PERs) Cryptochromes (CRYs). PERs CRYs constitute part negative feedback loop inhibit CLOCK:BMAL1-mediated transcription. Recently, we have shown patients with active ulcera...

This study documents the expression of prostacyclin (PGI2) synthase (PTGIS) and PGI2 receptors in the trophoblast and uterus of the ewe at the time of maternal recognition of pregnancy (i.e. days 7, 9, 12, 14 and 17). The membrane receptor for PGI2 (PTGIR) and the nuclear receptors, i.e. peroxisome proliferator-activated receptors (PPAR) and their heterodimer partners the retinoid X receptors (...

Aging is accompanied by major changes in adipose tissue distribution and function. In particular, with time, thermogenic-competent beige adipocytes progressively gain a white adipocyte morphology. However, the mechanisms controlling the age-related transition of beige adipocytes to white adipocytes remain unclear. Lysine-specific demethylase 1 (Lsd1) is an epigenetic eraser enzyme positively re...

Reactive oxygen species, ROS, are regulators of endothelial cell migration, proliferation and survival, events critically involved in angiogenesis. Different isoforms of ROS-generating NOX enzymes are expressed in the vasculature and provide distinct signaling cues through differential localization and activation. We show that mice deficient in NOX1, but not NOX2 or NOX4, have impaired angiogen...

DIDIER PORTILLA,1 GONGHE DAI,1 JEFFREY M. PETERS,3 FRANK J. GONZALEZ,3 MARK D. CREW,4 AND ALAN D. PROIA2 1Division of Nephrology, Department of Internal Medicine, University of Arkansas for Medical Sciences and John McClellan Memorial Veterans Hospital, Little Rock, Arkansas 72205; 2Department of Pathology, Duke University Medical Center Durham, North Carolina 27710; 3Laboratory of Metabolism, ...

Jackson AA, Burdge GC. Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPARa promoter of the offspring. Br J Nutr 2008;100:278–82. 21 Pfeifer GP. Mutagenesis at methylated CpG sequences. Curr Top Microbiol Immunol 2006;301:259–81. 22 Gluckman PD, Hanson MA. Developmental and epigenetic pathways to obesity: an evolutionary-...