A potentiometric non-enzymatic sensor using off-chip extended-gate field effect transistor (EGFET) with a ferrocenyl-alkanethiol modified gold electrode is demonstrated for determining the uric acid concentration in human serum and urine. Hexacyanoferrate (II) and (III) ions are used as redox reagent. This potentiometric sensor measures the interface potential on the ferrocene immobilized gold ...

Sensitive biosensors for detection of triglyceride concentration are important. In this paper we report on two types of silicon based triglyceride sensors: an electrolyte-insulator-semiconductor capacitor (EISCAP) which is a potentiometric device and a polysilicon microcantilever. The detection principle for both sensors is based on the enzymatic hydrolysis of triglyceride though the sensing me...

Among the techniques of detection used in clinical chemistry, optical and electrochemical methods are especially attractive. However, except for glass electrodes for pH measurement, potentiometric electrochemical sensors (ionselective electrodes) gained general acceptance in clinical analyzers and in clinical instrumentation, respectively, only around 1970 (for reviews see 1-5). Here we report ...

Miniature, potentiometric, solid-state, carbon monoxide (CO) sensors with semiconducting oxide electrodes were investigated over the temperature range 5001–7001C. The effects of the electrochemical properties of the semiconducting oxides, after the addition of a catalyst and an alkaline metal oxide were evaluated in terms of the improvement in selectivity and response time. A sensor with high s...

Recent progress in the design of new polymer membrane-based potentiometric ion-, gas- and bio-selective electrodes in chemistry laboratories at the University of Michigan (Ann Arbor) is reviewed. Emphasis is placed on describing the performance of devices for measuring anions (e.g., salicylate, thiocyanate, chloride and heparin) and gases (e.g., ammonia, carbon dioxide and oxygen) in biological...

This report describes the design and development of an integrated electrochemical cell culture monitoring system, based on enzyme-biosensors and chemical sensors, for monitoring indicators of mammalian cell metabolic status. MEMS technology was used to fabricate a microwell-format silicon platform including a thermometer, onto which chemical sensors (pH, O2) and screen-printed biosensors (gluco...

We report here on an electrogenerated chemiluminescence (ECL) readout for potentiometric ion-sensors, thereby offering an optical sensor output without the need for a reference ion (typically the hydrogen ion) that inconveniences ionophore based optical sensor principles. The compartment for ECL generation is physically separated from the sample by a bridge, and no current flows through the sam...

New rapid, sensitive and simple electrometric method was developed to determine sertraline hydrochloride (Ser-Cl) in its pure raw material and pharmaceutical formulations. Membrane sensors based on heteropolyacids as ion associating material were prepared. Silicomolybdic acid (SMA), silicotungstic acid (STA) and phosphomolybdic acid (PMA) were used. The slope and limit of detection are 50.00, 6...

A potentiometric electronic tongue was applied to study the release of valsartan from pharmaceutical formulations, i.e., minitablets uncoated and coated with Eudragit E. Special attention was paid to evaluate the influence of medium temperature and composition, as well as to compare the performances of the sensor arrays working in various hydrodynamic conditions. The drug dissolution profiles r...

Urinary Iodine has been widely regarded as a biochemical marker for control of iodine deficiency disorders. Based on the Sandell-Kolthoff reaction, most colorimetric assay methods for urinary iodine (UI) determination that have been developed require pretreatment of urine sample. The non-Sandell-Kolthoff methods for UI assay provide alternative approaches for UI assay requiring only simple pret...