The impact of pentylenetetrazol-induced kindling on the effectiveness of theta pattern primed-bursts (PBs) for the induction of long-term potentiation (LTP) of field excitatory postsynaptic potentials (fEPSP) and population spikes (PS) were investigated in hippocampal CA1 of pentylenetetrazol-kindled rats in vivo. The results showed that shortly after kindling, control animals had normal LTP of...

Observations have been made upon the nature of early and late post-tetanic potentiation and upon post-tetanic block of presynaptic collaterals with particular reference to behavior in circumstances of varied duration and frequency of conditioning stimulation. Early potentiation is most conspicuous following brief tetani at high frequency, late potentiation following long tetani, much lower freq...

The role of a neuron in neural processing is ultimately determined by whether or not it fires an action potential in a given context. Studies on synaptic plasticity have focused primarily on changes in EPSPs, and not on whether plasticity translates into changes in firing. However, this issue has been addressed by examining EPSP-spike (E-S) potentiation, which enhances the ability of an EPSP of...

The current study investigates whether the spinal pelvic nerve-to-external urethra sphincter (EUS) reflex potentiation can be induced by a mechanical stimulation and whether the glutamatergic mechanism is involved in yielding such a reflex potentiation. The external urethra sphincter electromyogram (EUSE) activity, evoked by a single or by repetitive pelvic nerve stimulation, in 30 anesthetized...

When muscle is elongated, there is a length dependence of twitch potentiation and an increased Ca(2+) sensitivity of the myofilaments. Changes in the charge potential of myofilaments, induced by a decrease in pH, are known to abolish the length dependence of Ca(2+) sensitivity. This study was aimed at testing the hypothesis that a decrease in pH, and the concomitant loss of length dependence of...

We report that substitution of sodium with lithium (Li+) in the extracellular solution causes subtype-specific changes in the inward and outward currents of glutamate receptors (GluRs), without a shift in reversal potential. Li+ produces an increase of inward and outward currents of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors and decreases in the currents of kainate (KA) and...

Zhang X, Daugherty SL, de Groat WC. Activation of CaMKII and ERK1/2 contributes to the time-dependent potentiation of Ca response elicited by repeated application of capsaicin in rat DRG neurons. Am J Physiol Regul Integr Comp Physiol 300: R644–R654, 2011. First published December 22, 2010; doi:10.1152/ajpregu.00672.2010.—When capsaicin is applied repeatedly to dorsal root ganglion (DRG) neuron...

introduction: the hippocampus was recognized as an important focus of epileptic seizures. a long-term potentiation (ltp) like that of epileptiform activities is considered as synaptic which has been observed for the first time in hippocampal formation. the purpose of the present study was investigating the synaptic plasticity induced by tetanic stimulation at ca1 area of the rat hippocampal sli...

noise induced hearing loss (nihl) is one of the most important occupational disease worldwide. nihl has been found potentiate by simultaneous carbon monoxide (co) exposure. free radicals have been implicated in cochlear damage resulted from the exposure to noise and due to the co hypoxia. this study examined whether α-tocopherol administration, as a free radical scavenger, causes the attenuatio...