Introduction ield experience and research demonstrate that manure nutrients can be readily substituted for commercial fertilizer. Fertilizer needs depend on soil test levels. Substituting manure at a lower cost than commercial fertilizer can result in signifi cant savings if relatively uniform application and distribution can be maintained. The less nutrient-dense manure requires more hauling o...

A series of phthiobuzone analogs, prepared from potassium phthalimide or phthalandione, have been evaluated for their antiviral activities. Among the candidates, compounds 5j and 5k, which contain the substituted 4-halogenated phenyl ring at N-4',4'' position, show more potent antiviral activity than phthiobuzone against herpes simplex virus 1 (IC(50)=8.56 and 2.85 microg/ml, respectively) and ...

A series of N-[3-{(1H-benzo[d]imidazol-2-ylthio) methyl}-5-mercapto-4H-1, 2, 4-triazol-4yl]-2-substituted phenoxy acetamide 6(a-g) were synthesized by the mixture of the compound of potassium 2-(2-(1H-benzo[d]imidazol-2-ylthio) acetyl) hydrazinecarbodithioate (4) and aryloxy acid hydrazide (5) in presence of hydrochloric acid. The predicted structures of the synthesized compounds were confirmed...

cholamines. JOEL G. HARDMAN AND STEVEN E. MAYER 29 Antagonism of Monoamine Oxidase Inhibitors against Norepinephrine, Acetyicholine and Potassium in the Isolated Nictitating Membrane of the Cat. T. H. TSAI AND W. W. FLEMING 40 A St.udy of the Potentiation of Tryptamine by Monoamine Oxidase Inhibitors in the Dog. JOHN NELSON EBLE 48 Pharmacology of a Group of Phenylpiperazine Tetrazole Derivativ...

an octahedral cobalt(iii) complex, trans-[(me2bpb)co(bzlan)2]clo4 (1), with h2me2bpb = n,n’-(4,5-dimethyl-1,2-phenylene)dipicolinamide and bzlan = benzylamine, has been synthesized and characterized by elemental analyses, ir, uv-vis, and 1h nmr spectroscopy. the structure of this complex has been determined by x-ray crystallography. the me2bpb2– is a di-anionic tetradentate ligand furnishing a ...

one-pot preparation of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles has been conducted in the presence of poly(4-vinylpyridinium butane sulfonic acid) hydrogen sulfate, p(4vpbsa)hso4, as an efficient dual acidic catalyst under solvent-free conditions. reusability of the catalyst, easy work-up procedure, eco-friendly reaction conditions, short reaction times and high yields of th...

Thiazolidine-4-one substituted 1, 2, 4triazole and benzofuran heterocyclic have received considerable attention during last two decades as they are endowed with variety of biological activities and have wide range of therapeutic properties. A literature survey indicates that benzofuran derivatives possess different pharmacological and biological activities, of which the most potent is anti-micr...

A general approach to 6-phenylthio-substituted 2,3,4,5-tetrahydro-1H-1,3-diazepin-2-ones based on the ring expansion reaction of 1,2,3,4-tetrahydropyrimidin-2-ones under the action of nucleophiles has been developed. The first step of the synthesis was preparation of N-[(2-benzoyloxy-1-tosyl)ethyl]urea by three-component condensation of 2-benzoyloxyethanal, urea and p-toluenesulfinic acid. Nucl...

Strongly inwardly rectifying potassium channels exhibit potent and steeply voltage-dependent block by intracellular polyamines. To locate the polyamine binding site, we have examined the effects of polyamine blockade on the rate of MTSEA modification of cysteine residues strategically substituted in the pore of a strongly rectifying Kir channel (Kir6.2[N160D]). Spermine only protected cysteines...