A sensitive, stability-indicating reversed-phase high-performance liquid chromatographic method is developed and validated for the quantitative determination of retapamulin in topical dosage form. The chromatographic separation is achieved by using a C18 column (XTerra RP 18 250 × 4.6 mm, 5 µm) at 30°C. The mobile phase comprises a mixture of 0.05M potassium dihydrogen phosphate buffer (pH 6.1)...

AIM AND BACKGROUND Three simple, accurate and sensitive spectrophotometric methods for the determination of finasteride in pure, dosage and biological forms, and in the presence of its oxidative degradates were developed. MATERIALS AND METHODS These methods are indirect, involve the addition of excess oxidant potassium permanganate for method A; cerric sulfate [Ce(SO4)2] for methods B; and N-...

Two methods for determining ranitidine hydrochloride (RNH) in pure drug and in formulations using potassium iodate and dichlorofuorescein are described. Titrimetry involves the oxidation of RNH by a known excess of potassium iodate in acidic conditions followed by iodometric determination of surplus iodate. In spectrophotometry also, the drug is oxidized by a large excess of iodate and the iodi...

Anesthetics are thought to mediate a portion of their activity via binding to and modulation of potassium channels. In particular, tandem pore potassium channels (K2P) are transmembrane ion channels whose current is modulated by the presence of general anesthetics and whose genetic absence has been shown to confer a level of anesthetic resistance. While the exact molecular structure of all K2P ...

A pot experiment was conducted at screen house of Department Soil Science, PAU, Ludhiana during rabi 2017-18 to evaluate the response wheat applied potassium. Twelve soil samples were taken from all over Punjab varying in available K. Potassium @ 0, 15, 20, 25 and 30 kg K/ha soil. The mean grain yield varied 12.39 20.13 g/pot K sufficient soils (>137 K/ha) 8.43 12.09 deficient (<137 K/ ha...

The pasture and forest land use change to agricultural use can effect on many properties of the soil and its productivity. The present research aims to investigate various forms of K (soluble, exchangeable, non-exchangeable, and structural forms) and some soil properties in different land use of three areas including Choram, Kakan and Bahmaei in Kohgiluyeh and Buyer-Ahmad Province. Four profile...

Potassium is among the three essential macronutrients for tea plants, along with nitrogen and phosphorous, plays important roles in growth stress response. absorbed by plants larger amounts than any other mineral element except and, some cases, calcium. At present, more 59% of China’s gardens are a state potassium deficiency, which negatively affects quality yield. This paper reviews effects de...

An enzymatic system in cell membranes actively transports sodium ions outward and potassium ions inward. Like other enzyme systems this one has a st,oichiometry and presumably, a reaction sequence and active sites. Knowledge of the latter feat,ures is fragmentary. Isolation of a reaction intermediate would clarify the reaction sequence and could lead to chemical characterization of an active si...