objective: hexavalent chromium [cr (vi)] compounds are well-known environmental contaminants  generated from industrial processes. several studies have reported the harmful effects of cr (vi) on different organs, however, little is known about neurotoxic effects of cr (vi). the aim of this study is to investigate the toxic effects of cr (vi) on pc12 cells. methods: pc12 cells were cultured foll...

background: food borne pathogens are of the main concerns of food producers and consumers and escherichia coli and staphylococcus aureus create a lot of problems worldwide. the aim of this study was to evaluate antibacterial effects of monolaurin, sorbic acid and potassium sorbate on s. aureus and e. coli at different ph values and nacl concentrations. methods: micro-well dilution assay was use...

Background:The spread of drug-resistant microbial strains has led many studies for identifying, designing, and synthesizing new antimicrobial agents.The aim of this study was to evaluate antimicrobial effects of some synthesized potassium dithiocarbazinate derivatives against 6 Gram-negative and 4 Gram-positive bacteria as well as 2 molds and 1 yeast. Potassium salts of dithiocarbazinic acids w...

Herein, a synthesis of 2-phosphonodihydrofurans and 2-phosphonodihydropyrroles via 5-endo cyclization O-and N-propargylated compounds is described. The reaction promoted by potassium tert-butoxide allows fast access to interesting heterocycles which were easily converted into 2-arylated pyrroles under acidic conditions.

Small- and intermediate-conductance Ca(2+)-activated potassium channels, activated by Ca(2+)-bound calmodulin, have an important role in regulating membrane excitability. These channels are also linked to clinical abnormalities. A tremendous amount of effort has been devoted to developing small molecule compounds targeting these channels. However, these compounds often suffer from low potency a...