OBJECTIVE Very little information is known about the toxic effects of cadmium on somatic cells in mammalian testis. The objective of this study is to explore the toxicity of cadmium on piglet Sertoli cells. METHODS Sertoli cells were isolated from piglet testes using a two-step enzyme digestion and followed by differential plating. Piglet Sertoli cells were identified by oil red O staining an...

Present study has been undertaken to assess the toxicity of cadmium in vitro for viability of hepatocytes, lactate dehydrogenase leakage, glutathione and lipid peroxidation in Channa punctatus (Bloch), a freshwater snake head fish. Three concentrations of cadmium as cadmium chloride (0.1μg/ml; 3.0μg/ml and 5.0μg/ml) besides one control has been selected. Observations reveal that except lowest c...

Treatment of U-937 human promonocytic cells with the cAMP increasing agents isoproterenol plus theophylline decreased the basal level of heat-shock protein 70 (HSP70) mRNA. In addition, the cAMP increasing agents attenuated the increase in HSP70 mRNA and protein levels produced by cadmium chloride in U-937 and other human myeloid cell lines, reduced the capacity of cadmium treatment to generate...

the present study deals with the oral supplementation with (50, 100 and 150 ?g/ml) synergetic effect of potassium and magnesium chloride on the fat body glycogen, protein, total lipids and haemolymph trehalose, protein of fifth instar larvae of bombyx mori l (lepidoptera: bombycidae). the observed parameters significantly increased in all the treated groups when compared with those of the corre...

in order to study the effects of potassium application on uptake and allocation of nitrogen and seed protein on two lentil cultivars in rain-fed condition a factorial experiment based on randomized complete block design with three replications was conducted at ardabil research center for agriculture and natural resources, in 2008. three potassium levels (0, 30 and 60 kg.ha-1), three nitrogen le...

A model has been used to simulate potassium (K) uptake by wheat in a pot culture experiment. Three soils from India, namely Alfisol, Inceptisol and Vertisol, were differentially K exhausted by Sudan grass (Surghum vulgare var. Sudanensis) for a period of 280 days and were used to simulate potassium uptake by wheat (Triticum aestivum) and also to predict the amounts of K released or fixed during...

Cadmium is a heavy metal that has been shown to cause its toxicity in humans and animals. Many documented studies have shown that cadmium produces various genotoxic effects such as DNA damage and chromosomal aberrations. Ailments such as bone disease, renal damage, and several forms of cancer are attributed to overexposure to cadmium. Although there have been numerous studies examining the effe...

In a preliminary study, ewes received daily oral cadmium chloride administrations and cadmium concentration was measured in blood and tissues. A pharmacokinetic analysis of cadmium disposition was then carried out in ewes administered cadmium chloride iv and, 21 months later, orally in the same ewes. Pharmacokinetic parameters were analysed using a 3-compartment open model. The systemic availab...