Title of Document: POST-TRANSCRIPTIONAL REGULATION IN THE DROSOPHILA SEX DETERMINATION PATHWAY David M. Sturgill, Ph.D., 2012 Directed By: Brian Oliver, NIDDK, NIH Sexually reproducing organisms produce two very different phenotypes (males and females), by differential deployment of essentially the same gene content. This dimorphism provides an excellent model to study how transcriptomes are di...

Transcriptional regulation by transcription factors and post-transcriptional regulation by microRNAs constitute two major modes of regulation of gene expression. While gene expression motifs incorporating solely transcriptional regulation are well investigated, the dynamics of motifs with dual strategies of regulation, i.e., both transcriptional and posttranscriptional regulation, have not been...