BACKGROUND AND PURPOSE Both stroke and the apolipoprotein E (APOE) epsilon4 allele increase the risk of dementia. However, the interaction between stroke and APOE on dementia is still unclear. We addressed this topic by using a longitudinal design. METHODS We followed up a community cohort of 1301 subjects aged >/=75 years, who did not have dementia at baseline. Among them, 92 subjects had a ...

BACKGROUND AND PURPOSE There are few data on long-term cognitive outcomes after first-ever stroke. We aimed to study long-term cognitive transitions, rates of cognitive change, and factors associated with incident dementia and cognitive impairment-no dementia (CIND) 2 years after first-ever stroke. METHODS A population-based cohort of incident first-ever stroke cases (n=99; mean age, 69.9 yea...

BACKGROUND Seizures occur in 10% of stroke patients, but their predictors have not been clearly identified. Pre-existing dementia is present in 12-16% of stroke patients and, at the community level, patients with dementia have increased risk of seizures. However, the question of whether pre-existing dementia is associated with a higher risk of seizures after stroke has never been studied. AIM...

BACKGROUND AND PURPOSE Inconsistent information about incidence and determinants of poststroke dementia might be related to patient attrition, partly because of nonapplicability of formal neuropsychological testing to a large proportion of patients registered in a definite setting. METHODS Using a proxy-informant interview based on ICD-10 criteria, we determined dementia at stroke onset and 1...

BACKGROUND AND PURPOSE Several studies indicate that stroke increases the risk of dementia. Most of these studies lacked the ability to take accurately assessed prestroke cognitive function into account. Whether the effects of stroke merely unravel an ongoing underlying dementing process or in fact cause the dementia has implications for the prevention of dementia in persons with cerebrovascula...

BACKGROUND AND PURPOSE Stroke is associated with increased risk of dementia. There has been a decline in mortality from stroke among persons 65 and over in recent decades in the US. It is not clear, however, how this process has affected incidence of various dementias. METHODS We evaluated over time changes in stroke admission rates and survival, and in rates of newly diagnosed dementias (Alz...

OBJECTIVE To investigate the risk of dementia in patients with stroke who did and did not receive acupuncture treatment. DESIGN Retrospective cohort study. SETTING This study was based on Taiwan's National Health Insurance Research Database that included patients with stroke hospitalised between 1 January 2000 and 31 December 2004. PARTICIPANTS We identified 11 220 patients aged 50 years ...

Stroke is defined as a neurological deficit which lasts more than 24 h or leads to death, caused by focal acute injury the central nervous system with vascular origin. Strokes are one of greatest challenges in public health. As an acutely stressful event, strokes have been associated increased release stress hormone cortisol. Elevated cortisol has linked deleterious impacts on brain, particular...

Patients with dementia are at increased risk of stroke. Acetylcholinesterase inhibitors (AChEIs) have endothelial function protection effects and anti-inflammatory properties. We investigated the ischemic stroke risk in AChEIs use in dementia patients without stroke history. Using Taiwan National Health Insurance Database from 1999 to 2008, 37,352 dementia patients over 50 years old without str...