Cirrhosis of the liver is by far the most common cause of portal hypertension in the western world. Portal hypertension is a frequent clinical syndrome, defined by a pathological increase in the portal venous pressure. When the portal pressure gradient (the difference between pressures in the portal and the inferior vena cava veins: normal value below 6 mmHg) increases above 10-12 mmHg, complic...

Sinistral portal hypertension is a clinical syndrome of gastric variceal hemorrhage in the setting of splenic vein thrombosis due to a primary pancreatic pathology. The distinguishing features from other forms of portal hypertension are preserved liver function and a patent extrahepatic portal vein. The important causes include acute and chronic pancreatitis, pancreatic pseudocysts and pancreat...

Aim: Portal hypertension is a common disease with high mortality and poor prognosis, especially in the cases of bleeding due to portal hypertension, and secondary hypersplenism. Herein, we report a case-series of 6 patients who had bleeding from esophagus varices due to complicated portal hypertension and subsequently underwent splenectomy and selectively devascularization. Our objective was to...

Introduction The 2012 National Strategy for Biosurveillance1 calls for improved integration, synchronization, and coordination of national biosurveillance activities and acknowledges the benefits of collective knowledge through sharing and receiving of biosurveillance information via strengthened partnerships amongst international, federal, state, local, tribal, territorial, private sector, non...

Intrahepatic arterioportal fistulas (APF) are uncommon complications following hepatic trauma. Large fistulas can result in portal hypertension and cardiovascular compromise. A 46-year-old patient is described who presented with portal hypertension, variceal bleeding, and high output cardiac failure due to a large intrahepatic APF. Surgical closure of the APF by hepatic resection successfully r...

......................................... Received: 03-02-14 Accepted: 05-11-14 Abstract Ectopic varices (EV) in the jejunum are a rare vascular disorder which is associated with portal hypertension (5%). It is even rarer when it occurs without associated portal hypertension. We report a case of a patient without portal hypertension who had had chronic intestinal bleeding from varices located i...

Variceal disease and its management are of the utmost importance in the treatment of portal hypertension. Current guidelines are universal for management of variceal disease in portal hypertension. Classification and grading systems are numerous and differ according to geographical location. In this exhaustive review, the historical aspects of variceal disease, its classification and the gradin...

Congenital abnormalities were present in 12 out of 30 (40%) children with extrahepatic portal hypertension of unknown cause, but in only 2 out of 17 (12%) children with extnahepatic portal hypertension secondary to umbilical vein catheterization or omphalitis. The most frequent abnormalities in this series and in published reports were atrial septal defect, malformation of the biliary tract, an...

Pediatric portal hypertension management is a team approach between the patient, the patient's family, the primary caregiver, and specialty providers. Evidence-based practice guidelines have not been established in pediatrics. This article serves as a review for the primary care NP in the management of pediatric portal hypertension, discussing the etiology, pathophysiology, and clinical present...

To evaluate the effect of portal hypertension and diminished portal venous blood flow to the liver on hepatic regeneration, male rats were subjected to partial portal vein ligation and subsequently to a two-thirds partial hepatectomy. The levels of ornithine decarboxylase activity at 6 h after partial hepatectomy were greater (p less than 0.001) in the rats with prior partial portal vein ligati...