Pomegranate polyphenols are potent antioxidants and chemopreventive agents but have low bioavailability and a short half-life. For example, punicalagin (PU), the major polyphenol in pomegranates, is not absorbed in its intact form but is hydrolyzed to ellagic acid (EA) moieties and rapidly metabolized into short-lived metabolites of EA. We hypothesized that encapsulation of pomegranate polyphen...

Pomegranate (Punica granatum) peel was extracted with water: ethanol (1:1) at room temperature and the extract was evaluated for antioxidant potential against AAPH induced lipid peroxidation in vitro in mice synaptosomes. In addition, its neuroprotective efficacy against rotenone-induced mortality, motor deficits and oxidative stress in Drosophila melanogaster was also assessed. Extract showed ...

Oils are important food ingredients, mainly as a source of unsaturated fatty acids. The offer of novel edible oils from herbs, spices and fruit seeds has grown and many of them are used as functional food and dietary supplements but also as feed additives in animal feeding. Poultry meat is recommended.in properly balanced diet and its consumption in Poland has been growing. The objective of pre...

This study reports lovastatin production by solid state fermentation using pomegranate seeds as a substrate. Six different fungal strains and several agro-industrial wastes were selected and screened. Various physicochemical parameters were optimized to improve lovastatin productivity. Moreover, chemical mutation was system-atically employed to enhance lovastatin yield on selected strains. Prod...

BACKGROUND Pomegranate extract (PE) is a standardized whole-fruit extract of pomegranate, a fruit with known anticancer properties. MATERIALS AND METHODS PANC-1 and AsPC-1 human pancreatic cancer cells were used as in vitro models to test the effects of PE. RESULTS PE treatment induced cell cycle arrest and inhibited cell proliferation in PANC-1 cells. PE treatment increased the proportion ...

Arils from six pomegranate (Punica granatum L.) varieties grown in the Mediterranean region of Turkey were tested for their antimicrobial properties by the agar diffusion and minimum inhibitory concentration (MIC) methods against seven bacteria: (Bacillus megaterium DSM 32, Pseudomonas aeruginosa DSM 9027, Staphylococcus aureus Cowan 1, Corynebacterium xerosis UC 9165, Escherichia coli DM, Ente...

Pomegranate and pomegranate juices (PJs) have taken great attention for their health benefits in the last years. As there is an increasing concern about potential health benefits of ellagic acid, it is of great interest to evaluate alterations in ellagic acid concentration of commercial PJs. The purpose of this study is to analyze total phenolic, free and total ellagic acid content of six comme...

Advanced Glycation Endproducts (AGEs) are a heterogeneous group of molecules produced from non-enzymatic glycation. Accumulation of AGEs in vivo plays an important role in the pathology of chronic human diseases including type-2 diabetes and Alzheimer's disease. Natural AGEs inhibitors such as the pomegranate (Punica granatum) fruit show great potential for the management of these diseases. Her...

Diet and lifestyle have long been recognized as important modifiers of health status. Modern scientific methods are being used to uncover, demystify, and validate the benefits of dietary constituents in health promotion. Likewise, many different foods are currently being studied for their role in the management of numerous disorders and conditions ranging from metabolic and inflammatory disorde...

Pomegranate molasses (PM) is a large compound of the eastern diets, yet no research has been performed on this product. In this study, we measured the total polyphenols content of PM, compared to fresh pomegranate juice, obtaining 252.28 and 79.49 mg of Gallic Acid equivalent/L respectively. The antioxidant effect of PM and juice was then measured in vitro using electrolysis as a free radical g...