The first aim of the present investigation was to prepare solid dispersions to improve the dissolution properties of oxcarbazepine and quetiapine using PEG 6000 as a carrier with the help of two methods of preparations viz. spray drying and modified solvent method, and to compare the two methods. The second objective was to apply the modified solvent method for preparation of sustained re...

A composite foam of polyurethane/chitosan with chitosan content of 20 wt% was successfully prepared as an adsorbent for the removal of malachite green from aqueous solution, the structures and properties were characterized by scanning electron microscope and Fourier transform infrared spectroscopy. The results showed open cell content of polyurethane/chitosan was more than 95% and open cell str...

BACKGROUND As surgeons working in a developing country, we decided to review our experience with polyurethane stents instead of the more expensive ones on common urological procedures and analyzing our experience with respect to their usefulness versus their problems and outcome. METHODS This stusy was carried out at Armed Forces Institute of Urology, Rawalpindi and Combined Military Hospital...

Calcification complicates the use of the polymer polyurethane in cardiovascular implants. To date only costly experimental circulatory animal models have been useful for investigating this disease process. In this paper we report that polyurethane calcification in rat subdermal implants is enhanced by overdosing with a vitamin-D analog. The calcification-prone state, known as calciphylaxis, was...

Colloidal hard-sphere (HS) particles of narrow-size distribution exhibit crystalline and glassy states beginning at the particle volume fractions phi = 0.494 and phi(G) = 0.58, respectively. Dynamic rheological data on the dispersions were strongly modified to solid-like behavior as phi approached phi(G). In addition, cooperative motion in structural relaxation has been observed microscopically...

Topical hemostatic agents can be used to treat problematic bleedings in patients who undergo surgery. Widely used are the collagen- and gelatin-based hemostats. This study aimed to develop a fully synthetic, biodegradable hemostatic agent to avoid exposure to animal antigens. In this in vitro study the suitability of different newly developed polyurethane-based foams as a hemostatic agent has b...

The aim of the present study was to improve solubility and dissolution of the poorly aqueous soluble drug, etoricoxib by solvent evaporation technique using various sugar carriers, such as lactose, sucrose, and mannitol. Etoricoxib solid dispersions and their respective physical mixtures using lactose, sucrose, and mannitol were prepared in different ratios by solvent evaporation technique. The...

In recent years, adhesive wound dressings have been increasingly applied postoperatively because of their ease of use as they can be kept in place without having to cut and apply surgical tapes and they can cover a wound securely. However, if a wound dressing strongly adheres to the wound, a large amount of stratum corneum is removed from the newly formed epithelium or healthy periwound skin. V...

The objective of the present investigation was to study the effect of polyethylene glycol 4000 (PEG 4000) on in vitro dissolution of gliclazide from solid dispersions. Initial studies were carried out using physical mixtures of the drug and carrier. Solid dispersions were prepared by the melting or fusion method.Phase and saturation solubility study, in vitro dissolution of pure drug, physical ...

Rheological studies of the ceramic based concentrated titania nanoparticle dispersions showed a clear correlation between molecular structure of the cationic polymers used as dispersants and the viscosity of the slurries. Dynamic viscosity of the electrostatically stabilized alkaline (pH 10.0) dispersions of the bare titania nanopowders with a solid loading of 15 – 25 wt.% was rather high (abou...