The crystal structures are reported for two unsubstituted arylnaphthalene lactones, 4-phenylnaphtho[2,3-c]furan-1(3H)-one (2), 9-phenylnaphtho[2,3-c]furan-1(3H)-one (3) and a non-aromatic dihydro arylnaphthene lactone, 3a,4-dihydro-9-phenylnaphtho[2,3-c]furan-1(3H)-one (5). There only minor differences in the geometrical parameters of these structures. However, certain cases, both isomers lacto...

The novel compound 2-(1H-imidazol-2-yl)-2,3-dihydro-1H-perimidine was obtained in very good yield via a known eco-friendly protocol. product isolated pure form as solvate by simple filtration from the crude mixture. Its structure assigned 1D and 2D NMR experiments confirmed high resolution MS single crystal XRD. temperature of methanol release determined DSC energy process theoretically estimat...

Abstract New convenient synthetic methods in pyrazoline and pyrazolooxazine chemistry have been developed starting from 2,2‐dichlorovinylacetophenones 4 , whose reaction with 2‐hydroxyethylhydrazine directly gave hitherto unknown 3‐aryl‐5‐dichloromethyl‐1‐(2‐hydroxiethyl)‐2‐pyrazolines 7 high yields. These were found to be able undergo cyclization afford 2‐aryl‐6,7‐dihydro‐4 H ‐pyrazolo[5,1‐ c ...

The compounds 1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl nitrate (C1), (1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl nitrate (C2), 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzyl nitrate (C3), 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-hydroxy-benzenesulfonamide (C4), 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzyl nitrate (C5), and 2-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]eth...

In this study, theophylline (1) compounds were synthesized with addition of 2-bromoetha-nol, 2-bromoacetamide and methyl-2-bromoacetate to attain symmetric connections NHCs (2a–c). New complexes containing the N-heterocyclic carbene (NHC) ligands using azolium salts in dimethyl formamide (DMF). After NHC predecessor reacted Ag2O, Ag(I)-NHC following: 7,9-di-(2-hydroxyethyl)-8,9-dihydro-1,3-dime...

The combination of organolithium chemistry with gold catalysis has enabled the development a synthetic strategy for accessing polysubstituted indoles and carbazoles from readily available starting materials. This method is based on “back-to-front” approach ketopyrroles, generated by intramolecular carbolithiation N,N-bis-(2-lithioallyl)amines that evolve into 3,4-bis(lithiomethyl)dihydropyrrole...

The 2-aryl-6,8-dibromo-4-chloroquinazolines derived from the 2-aryl-6,8-dibromoquinazolin-4(3H)-ones were subjected to the Sonogashira cross-coupling with terminal acetylenes at room temperature to afford novel 2-aryl-6,8-dibromo-4-(alkynyl)quinazoline derivatives. Further transformation of the 2-aryl-6,8-dibromo-4-(phenylethynyl)quinazolines via Suzuki-Miyaura cross-coupling with arylboronic a...

The multicomponent reaction (MCR) of aromatic aldehydes 1 and malononitrile (2) with active methylenes 5a-h in the presence of L-proline produced pyrans and thiopyrans 6a-h stereospecifically and in good yields. Moreover a novel MCR of ethyl propiolate (8) with 1 and 2 in the presence of L-proline to afford (R)-polysubstituted pyran is also reported. X-ray structures, e.e. and optical activity ...

The title compound, C(28)H(20)F(2)O(2), is a polysubstituted terphenyl derivative bearing a Michael system. The C=C double bond is E configured. In the crystal, C-H⋯O and C-H⋯F contacts connect the mol-ecules, forming undulating sheets that lie perpendicular to the crystallographic a axis. The shortest π-π inter-action [centroid-centroid distance = 3.7163 (7) Å] involves the para-fluoro-phenyl ...