Sulphate is an obligate nutrient for healthy growth and development. Sulphate conjugation (sulphonation) of proteoglycans maintains the structure and function of tissues. Sulphonation also regulates the bioactivity of steroids, thyroid hormone, bile acids, catecholamines and cholecystokinin, and detoxifies certain xenobiotics and pharmacological drugs. In adults and children, sulphate is obtain...

HS (heparan sulphate) plays a key role in angiogenesis, by interacting with growth factors required in the process. It has been proposed that HS controls the diffusion, and thus the availability, of platelet-derived growth factor B that is needed for pericyte recruitment around newly formed capillaries. The present paper summarizes our studies on the importance of HS structure in this regulator...

Interesting synergism in vitro between a recently introduced antibiotic, colistin methane sulphonate, and sulphonamide drugs is described. The observations were extended to polymyxin B sulphate and sulphonamides with essentially similar results. The combinations are bactericidal at therapeutic levels, the ratio of drugs to one another is not critical, and the effect is present over a fairly wid...

1. N-Acetylgalactosamine 6-sulphate sulphatase was purified about 20000-fold from the soluble extract of human placenta with N-acetylgalactosamine 6-sulphate-glucuronic acid-N-acetyl[1-(3)H]galactosaminitol 6-sulphate as substrate in the activity assay. The enzyme appears to be a glycoprotein with a mol.wt. of about 100000 as determined by gel filtration. On gel electrophoresis in the presence ...

Antioxidant capacity of poorly soluble natural antioxidant kaempferol, in particular free or loaded two types cationic micelles, was studied on non-enzyme induced lipid peroxidation (LPO) vitro . The micelles were based triblock copolymers - poly(2-(dimethylamino)ethyl methacrylate-b-poly(propylene oxide)-b-poly(2-(dimethylamino)ethyl methacrylate (PDMAEMA-PPO-PDMAEMA) and methacrylate-b-poly(ε...

The widespread occurrence of sulphatases in the Mollusca was first demonstrated by Soda & Hattori (1933a, b) who showed that these enzymes are mainly concentrated in the digestive glands. That extracts from marine molluscs also possess ,B-glucuronidase activity was first noted by Dodgson, Lewis & Spencer (1952) who studied the optimum conditions for the activity ofthis enzyme and arylsulphatase...

The structural and electrical properties of polyaniline-cobalt sulphate nanocomposite prepared by chemical method.Polyaniline-cobalt sulphate nanocomposites were synthesized by the cobalt sulphate and ammonium persulphate and aniline.This paper reports on chemical technique using for synthesis of cobalt nanoparticles in the composite bridge is aniline. Electrical conductivity of polyaniline wit...

The structural and electrical properties of polyaniline-cobalt sulphate nanocomposite prepared by chemical method.Polyaniline-cobalt sulphate nanocomposites were synthesized by the cobalt sulphate and ammonium persulphate and aniline.This paper reports on chemical technique using for synthesis of cobalt nanoparticles in the composite bridge is aniline. Electrical conductivity of polyaniline wit...

BACKGROUND/AIMS To investigate whether transit time could influence H2 consuming flora and certain indices of colonic bacterial fermentation. METHODS Eight healthy volunteers (four methane excretors and four non-methane excretors) were studied for three, three week periods during which they received a controlled diet alone (control period), and then the same diet with cisapride or loperamide....