The field of biomedical engineering highly demands technological improvements to allow the successful engraftment biomaterials requested for healing damaged host tissues, tissue regeneration, and drug delivery. Polymeric materials, particularly natural polymers, are one primary suitable materials employed functionalized enhance their biocompatibility thus confer advantageous features after graf...

Several polymers are researched for tendon repair as polyethylene terephthalate (PET) and polylactic acid (PLA). These biocompatible useful in scaffolding though with minimal success due to long-term failure. There is a need improve such scaffolds' design physical–chemical nature. This work concerns surface functionalization of polymeric braids (PET PLA) that fulfill the high mechanical demands...

Human tissues and organs exhibit complex hierarchical gradient structures that are essential to their function should be recapitulated within biomaterial scaffolds targeting regeneration. Unidirectional freezing, an ice templating technique where acts as a porogen, is uniquely suited recapitulating the architectural anisotropy, gradients, transitions of human tissues, but polymeric systems, inc...

In this work, we first tested the influence of low-molecular-weight (LMW) fucoidan extracted from pheophicae cell wall on bidimensional cultured normal human osteoblasts' behaviors. Second, by impregnation procedure with LMW fucoidan of bone biomaterial (Lubboc), we explored in this bone extracellular matrix context its capabilities to support human osteoblastic behavior in 3D culture. In bidim...

In many biomedical applications, the performance of biomaterials depends largely on their degradation behavior. For instance, in drug delivery applications, the polymeric carrier should degrade under physiological conditions slowly releasing the encapsulated drug. The aim of this work was, therefore, to develop an enzymatic-mediated degradation carrier system for the delivery of differentiation...

Advancements in the biomedical field are driven by the design of novel materials with controlled physical and bio-interactive properties. To develop such materials, researchers rely on the use of highly efficient reactions for the assembly of advanced polymeric scaffolds that meet the demands of a functional biomaterial. In this thesis two main strategies for such materials have been explored; ...