The decrease of the molecular size of poly(I.C) to less than 10(6) decreases its ability to induce interferon, protect mice against virus, or enhance the immune response. Immune adjuvant activity appeared more sensitive to molecular weight than the other protective activities. The composition of the complex-the molecular size of the individual homopolymers when one was large and the other small...

The compounds produced by a living organism are most commonly as medicinal agents and starting materials for the preparation of new semi-synthetic derivatives. One of the largest groups of natural compounds consists of products containing a 1,4-benzoquinone subunit. This fragment occurs in three enediyne antibiotics, dynemicin A, deoxydynemicin A, and uncilamicin, which exhibit high biological ...

several 10-substituted anthralins were readily prepared. their oxidation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone gave the corresponding novel heteroatomic systems. all derivatives were fully characterized by ir, mass and 1hnmr spectroscopy.

We present a quantum chemical study of oxidation of phenoxy and benzyl radicals by HO2. All calculations were carried out using the modified Perdew-Wang (MPW1K) density functional method. We found that adsorption of HO2 in the ortho and para positions of the aromatic ring leads to stable phenyl-OOH and benzyl-OOH adducts with dissociation energies from 16 to 27 kcal/mol. Calculations indicate t...

Several 10-substituted anthralins were readily prepared. Their oxidation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone gave the corresponding novel heteroatomic systems. All derivatives were fully characterized by IR, Mass and 1HNMR spectroscopy.  

The fast and selective determination of hydrogen peroxide (H2O2) is importance not only because strong interest in this widely applied analyte, but also the development enzymatic biosensors for glucose or other metabolites where sensor H2O2 can be used as transducer. Here, we report on an electrocatalytical amperometric detection H2O2. It a that consists gold electrode covered by self-assembled...

1,4-Benzoquinone is cytotoxic in V79 Chinese hamster cells and induces gene mutations and micronuclei. The cell-damaging effects of quinones are usually attributed to thiol depletion, oxidation of NAD(P)H, and redox-cycling involving the formation of semiquinone radicals and reactive oxygen species. To elucidate the role of these mechanisms in the genotoxicity of 1,4-benzoquinone, we measured v...