General pharmacology in -the seventeenth and eighteenth centuries is considered (Parts 1 and 2). Reference is made to some criticisms of the contemporary materia medica and -to early attempts at a scientific investigation of drugs and poisons. The studies of vegetable drugs by Stoerk and Withering are discussed to illustrate the problems associated with pharmaco-dynamic studies in clinical prac...

The two known antineoplastic quinoxaline topoisomerase II poisons, XK469 (NSC 697887) and CQS (chloroquinoxaline sulfonamide, NSC 339004), were compared for DNA cleavage site specificity, using purified human topoisomerase IIalpha and human topoisomerase IIbeta. The DNA cleavage intensity pattern for topoisomerase IIalpha poisoning by CQS closely resembled that of VM-26, despite the lack of any...

Chemically recycled monomer feed streams from postconsumer plastic packaging waste are expected to contain impurities that act as catalyst poisons. This work investigates the impact of such on a commercial fourth-generation Ziegler–Natta system. A stream in two different procedures by adding representative poisons (pyridine and n-butanol) various quantities reactor setup is simulated. Measuring...

Poisons always have fascinated humankind. Initially considered as deleterious or hazardous substances, the modern era has witnessed controlled utilization of dangerous poisons in medicine and cosmetics. Simultaneously, antidotes become crucial reversal agents to counteract effects a poison, they are also used today positively cancel benefits poison after use. Currently, majority composed small ...

You’re late for work, and it’s pouring rain. In the parking lot, a car speeds around you and takes the last spot near the building entrance. You end up trudging from the back of the lot and get soaked to the skin. You’re mad, and you know your judgment at the moment is probably impaired. Worse, the leftover anger will continue to color your decisions at work, our research suggests, without your...

Topoisomerase II (TOP2)-targeting poisons such as anthracyclines and etoposide are commonly used for cancer chemotherapy and kill tumor cells by causing accumulation of DNA double-strand breaks (DSB). Several lines of evidence indicate that overexpression of TOP2A, the gene encoding topoisomerase IIα, increases sensitivity of tumor cells to TOP2 poisons, but it is not clear why some TOP2A-overe...