A simple versatile method for the conversion of benzy1idene)-hydrazines to 1 -aryl-phthalazines using polyphosphate ester (PPE) is described 1 -aroyl-2-( substituted Podophyllotoxin ( I ) , a cytotoxic constituent of the plant species podophyllum peltatum has attracted considerable research activities, which culminated in the synthesis of tenoposides, and etoposides, which are now clinically us...

Etoposide is a chemotherapy drug derived from the natural lignin podophyllotoxin. Our novel generated Aza-podophyllotoxin compounds (AZP 8a & AZP 9a) are analogues of podophyllotoxin and were previously screened for anti-cancer activity through the NCI 60 cell line screening panel showing activity on various cell types including colon cancer. This study expands the toxicological screening by st...

The quality and quantity of medicinal plants are serious issues for the pharmaceutical and dietary supplement industries. Traditionally, this material has been harvested from the wild, and while cultivation procedures have been developed for supplements such as St. John’s Wort, this is still the general method employed for the majority of medicinal plants. Increasing public demand for these pro...

Precursors of podophyllotoxin were synthesized and screened for their antibacterial activity. The results proved that ethyl-2-(3'-methyl-4'-methoxybenzoyl)-3-(4″ methoxyphenol)-cyclopropane-1-carboxylic acid and Ethyl-2-(3'-methyl-4'-methoxybenzyol-3-1 3″, 4″-dimethoxyphenyl)-cyclopropane-carboxylic acid have significant antibacterial activity against Citrobacter sp., Escherchia coli, Klebsiell...

Five new 4-aza-2,3-didehydropodophyllotoxins were synthesized by a straightforward multi-component reaction in the hope of finding structures with interesting anticancer activity. The “one-pot” synthesis process is developed to increase performance as well minimize steps involved. obtained compounds podophyllotoxin frame have corresponding yields 60-83%. demonstrated comparable cytotoxicity aga...